C. Yding Andersen, K. Vilbour Andersen Reproductive BioMedicine Online

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Presentation transcript:

Improving the luteal phase after ovarian stimulation: reviewing new options C. Yding Andersen, K. Vilbour Andersen Reproductive BioMedicine Online Volume 28, Issue 5, Pages 552-559 (May 2014) DOI: 10.1016/j.rbmo.2014.01.012 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Relationship between mid-luteal-phase progesterone concentration measured 7days after oocyte retrieval and early pregnancy loss rate (Humaidan et al., 2005, 2010, 2013; see also Table 1). Reproductive BioMedicine Online 2014 28, 552-559DOI: (10.1016/j.rbmo.2014.01.012) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Concentration profiles of HCG following trigger injection. (A–C) Circulatory concentration (solid lines) and endogenous HCG development from the implanting embryo (dashed lines) after exogenous administration of 250μg recombinant HCG (Trinchard-Lugan et al., 2002), fitted to represent a fit to a pharmacokinetic model with first-order absorption and linear elimination including a lag time, with the assumption that 250μg=6500IU (A) and scaled versions of the fit in A representing 5000IU (B) and 10,000IU (C). (D) Endogenous LH bust following GnRH agonist trigger (Itskovitz et al., 1991) (solid lines) and endogenous HCG development from the implanting embryo based on experimental data of singleton pregnancies from days 14–24 after trigger, based on a model of a smooth increase, resulting in the first significant HCG concentration between days 6 and 7 after oocyte retrieal and reaching experimental concentration on day 12.5 (Sherbahn, 2013; dashed lines). A2, B2, C2 and D2 are zoomed versions of A1, B1, C1 and D1. Reproductive BioMedicine Online 2014 28, 552-559DOI: (10.1016/j.rbmo.2014.01.012) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions