Association of sustained cardiovascular recovery with epinephrine in the delayed lipid- based resuscitation from cardiac arrest induced by bupivacaine.

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Presentation transcript:

Association of sustained cardiovascular recovery with epinephrine in the delayed lipid- based resuscitation from cardiac arrest induced by bupivacaine overdose in rats B. Li, J. Yan, Y. Shen, B. Li, Z. Hu, Z. Ma British Journal of Anaesthesia Volume 108, Issue 5, Pages 857-863 (May 2012) DOI: 10.1093/bja/aes018 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Haemodynamic changes during resuscitation. Mean (sd) arterial pressure (a), heart rate (b), and native RPP (c) are plotted against time. Two-way analysis of variance with repeated measures and Bonferroni post-tests were used to compare mean differences over time within and between groups. Significance of differences is shown for epinephrine plus lipid vs saline (*), epinephrine vs saline (+), lipid vs saline (†), epinephrine plus lipid vs lipid only (#). **P<0.01, #P<0.05, ##P<0.05, †P<0.05, +P<0.05, ++P<0.01; n=8 for each group. British Journal of Anaesthesia 2012 108, 857-863DOI: (10.1093/bja/aes018) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Mean (sd) CPP at 11 min. One-way analysis of variance followed by Bonferroni post-tests was used to compare mean values among various groups. Significance of differences is also shown for epinephrine plus lipid vs saline (P=0.002) or lipid only (P=0.005) and epinephrine only vs saline (P=0.017) or lipid only (P=0.036), n=8 for each group. British Journal of Anaesthesia 2012 108, 857-863DOI: (10.1093/bja/aes018) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 Median (IQR) myocardial bupivacaine content at 25 min. The Kruskal–Wallis test followed by Dunn's post-test was used to compare the median values. Significance of differences is also shown for epinephrine plus lipid vs saline, lipid only, or epinephrine only (*). *P<0.05, n=8 for each group. British Journal of Anaesthesia 2012 108, 857-863DOI: (10.1093/bja/aes018) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 Mean (sd) wet-to-dry lung weight ratio at 25 min. (a) Lung specimens from all rats in each group (n=8); (b) lung specimens from surviving rats given epinephrine only (n=2), lipid only (n=3), and epinephrine plus lipid (n=5). One-way analysis of variance followed by Bonferroni post-tests was used to compare mean values among groups. Significance of differences is shown for lipid only vs epinephrine only (P=0.042) or lipid vs epinephrine plus lipid (P=0.023). British Journal of Anaesthesia 2012 108, 857-863DOI: (10.1093/bja/aes018) Copyright © 2012 The Author(s) Terms and Conditions