Panel A Panel B Panel C History SCC before Pain study

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Panel A Panel B Panel C History SCC before Pain study Original Pain study Pain follow-up study No SCC/KA 145 No SCC/KA 162 No SCC 197 SCC/KA 50 No SCC/KA 288 Missing 2 SCC/KA 123 SCC 91 No SCC/KA 17 SCC/KA 73 Missing 1 Missing 3 No SCC/KA 13 Fig S1. Schematic representation of the original SCOPE-ITSCC PAIN study (Panel B), history of SCC before the SCOPE-ITSCC PAIN study (Panel A) and new or subsequent SCC/KA during the cohort study (Panel C). During the follow-up study 50 SCC/KA developed in the 197 patients who had never had SCC before; 73 SCC/KA developed in the 91 patients who had SCC before the PAIN study, but not when a biopsy was taken for the original PAIN study; 21 SCC/KA developed in the 34 patients who did not have a history of SCC prior to the original PAIN study but presented with an SCC/KA at the start of the original PAIN study and 70 SCC/KA developed in the 88 patients who had a history of SCC before and a new SCC/KA during the PAIN study (left side of Panel C). The numbers indicate the number of patients in the different categories. SCC: squamous cell carcinoma; KA: keratoacanthoma. SCC/KA 21 No SCC 34 SCC/KA 122 No SCC/KA 31 SCC 88 SCC/KA 91 No SCC/KA 18 SCC/KA 70 Panel A Panel B Panel C