Deep hypothermic circulatory arrest during the arterial switch operation is associated with reduction in cerebral oxygen extraction but no increase in.

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Presentation transcript:

Deep hypothermic circulatory arrest during the arterial switch operation is associated with reduction in cerebral oxygen extraction but no increase in white matter injury Paul P. Drury, BSc(Hons), Alistair J. Gunn, MBChB, PhD, Laura Bennet, PhD, Anusha Ganeshalingham, MBChB, Kirsten Finucane, MBChB, David Buckley, MBChB, John Beca, MBChB The Journal of Thoracic and Cardiovascular Surgery Volume 146, Issue 6, Pages 1327-1333 (December 2013) DOI: 10.1016/j.jtcvs.2013.02.011 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Intraoperative data for patients with and without deep hypothermic circulatory arrest (DHCA) are mean ± SEM. Time points are 5-minute averages beginning 30 minutes before and lasting until 30 minutes after cardiopulmonary bypass (CPB) initiation, from 10 minutes before and lasting until 10 minutes after aortic crossclamping, from 10 minutes before deep hypothermic circulatory arrest, minute averages of deep hypothermic circulatory arrest, deep hypothermic circulatory arrest nadir, deep hypothermic circulatory arrest off, minute averages for 5 minutes after deep hypothermic circulatory arrest, 5-minute average of 6 to 10 minutes after deep hypothermic circulatory arrest, from 10 minutes before and lasting until 10 minutes after aortic unclamping, and from 30 minutes before and lasting until 30 minutes after bypass off. Asterisk indicates P < .05 by post hoc contrasts. MAP, Mean arterial blood pressure; TOI, tissue oxygenation index, aEEG, amplitude-integrated electroencephalography; ΔHb, difference in hemoglobin; FTOE, fractional tissue oxygen extraction. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1327-1333DOI: (10.1016/j.jtcvs.2013.02.011) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Postoperative data for patients with and without deep hypothermic circulatory arrest (DHCA) are hourly mean ± SEM. Time 0 represents the end of bypass. Asterisk indicates P < .05 by post hoc contrasts. Sao2, Arterial oxygen saturation; MAP, mean arterial blood pressure; TOI, tissue oxygenation index, aEEG, amplitude-integrated electroencephalography; ΔHb, difference in hemoglobin; FTOE, fractional tissue oxygen extraction. The Journal of Thoracic and Cardiovascular Surgery 2013 146, 1327-1333DOI: (10.1016/j.jtcvs.2013.02.011) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions