Intensive Lowering of Low-Density Lipoprotein Cholesterol Levels for Primary Prevention of Coronary Artery Disease Dean G. Karalis, MD Mayo Clinic Proceedings

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Presentation transcript:

Intensive Lowering of Low-Density Lipoprotein Cholesterol Levels for Primary Prevention of Coronary Artery Disease Dean G. Karalis, MD Mayo Clinic Proceedings Volume 84, Issue 4, Pages 345-352 (April 2009) DOI: 10.4065/84.4.345 Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE Treatment algorithm for the primary prevention of coronary artery disease (CAD). The main changes in the updated National Cholesterol Education Program Adult Treatment Panel III guidelines are the lower low-density lipoprotein cholesterol (LDL-C) goal of less than 100 mg/dL for individuals with 2 or more CAD risk factors and a Framingham risk score of 10% to 20%. The presence of multiple or severe risk factors, an elevated level of C-reactive protein (CRP), or other risk factors identified in the updated guidelines justify more intensive LDL-C level lowering with drug therapy to achieve a lower LDL-C goal of less than 100 mg/dL. CAC = coronary artery calcium; HDL-C = high-density lipoprotein cholesterol; TG = triglycerides. SI conversion factors: To convert cholesterol (HDL-C, LDL-C) levels to mmol/L, multiply by 0.0259; to convert CRP values to nmol/L, multiply by 9.524; to convert TG values to mmol/L, multiply by 0.0113. Mayo Clinic Proceedings 2009 84, 345-352DOI: (10.4065/84.4.345) Copyright © 2009 Mayo Foundation for Medical Education and Research Terms and Conditions