Consequences of transplant quality on chronic allograft nephropathy Marc-Olivier Timsit, Xiaodong Yuan, Bernhard Floerchinger, Xupeng Ge, Stefan G. Tullius  Kidney International  Volume 78, Pages S54-S58 (December 2010) DOI: 10.1038/ki.2010.424 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Impact of organ quality on chronic allograft nephropathy. Donor age, and consequences of ischemia–reperfusion injury and brain death are the main determinants of organ quality. Cellular senescence is associated with impaired repair and increased sensitivity to nephrotoxic compounds. The impact of brain death injury includes broad consequences of inflammatory responses (‘cytokine storm’, activation of the complement cascade), sympathetic surge, oxidative stress, and hormonal changes. Determinants of organ quality may interact in a synergistic or additive manner and activate innate and adaptive immune responses through injury, compromised repair, or increased immunogenicity. Kidney International 2010 78, S54-S58DOI: (10.1038/ki.2010.424) Copyright © 2010 International Society of Nephrology Terms and Conditions