Histological and immunohistochemical evaluation of primary central nervous system lymphoma. Histological and immunohistochemical evaluation of primary.

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Presentation transcript:

Histological and immunohistochemical evaluation of primary central nervous system lymphoma. Histological and immunohistochemical evaluation of primary central nervous system lymphoma. Neoplastic cells have an angiocentric pattern, forming collars around blood vessels (A; original magnification, ×20; haematoxylin and eosin). At higher magnification the neoplastic cells are round with big nuclei and moderate eosinophilic cytoplasm (B; original magnification, ×100; haematoxylin and eosin). Immunohistochemical staining with anti-CD20 and anti-CD79α antibodies shows intense cytoplasmic and membrane associated reactivity in the neoplastic perivascular cells (C; original magnification, ×20; D, original magnification, ×100). Immunohistochemical staining with an antibody detecting JC virus T antigen shows expression in the nuclei of approximately 60% of the neoplastic lymphocytes (E; original magnification, ×40; F; original magnification, ×100). G L Gallia et al. Mol Path 2001;54:354-359 ©2001 by BMJ Publishing Group Ltd and Association of Clinical Pathologists