Representative images of human islets infected with strains of CVB Representative images of human islets infected with strains of CVB. (A) Immunohistochemical staining of insulin in islets infection with CVB5/V89-4557 6 days postinfection. Representative images of human islets infected with strains of CVB. (A) Immunohistochemical staining of insulin in islets infection with CVB5/V89-4557 6 days postinfection. Original magnifications ×20. (B) Electron micrograph of β-cells in different stages of necrosis in CVB5/Adr inoculated islet, showing presence of insulin (white arrows). CVB, coxsackievirus; M, mitochondria, N, nuclei, L, lipofuscin. M Hodik et al. BMJ Open Diab Res Care 2016;4:e000179 ©2016 by American Diabetes Association