Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease.

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Presentation transcript:

Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity Takashi Kakinuma, MD, Koichiro Nakamura, MD, Motoshi Wakugawa, MD, Hiroshi Mitsui, MD, Yayoi Tada, MD, Hidehisa Saeki, MD, Hideshi Torii, MD, Akihiko Asahina, MD, Nobuyuki Onai, MD, Kouji Matsushima, MD, Kunihiko Tamaki, MD Journal of Allergy and Clinical Immunology Volume 107, Issue 3, Pages 535-541 (March 2001) DOI: 10.1067/mai.2001.113237 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Serum TARC levels were elevated in patients with AD. A, Serum TARC levels in patients with AD (n = 40), healthy control subjects (n = 20), and patients with psoriasis (n = 20). B, Serum TARC levels among healthy control subjects (n = 20) and 3 groups of patients with AD: those with mild (n = 9), moderate (n = 23), and severe (n = 8) disease. Each vertical bar represents mean ± SE of total subjects in individual categories. C, The serum TARC levels of 10 patients with AD were evaluated before and after topical corticosteroid treatment. Serum TARC levels significantly decreased after treatment (P < .001). Journal of Allergy and Clinical Immunology 2001 107, 535-541DOI: (10.1067/mai.2001.113237) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Serum TARC levels in patients with AD correlated with disease activity. Comparison between serum TARC levels and SCORAD scores (A) , serum soluble E-selectin levels (B) , or eosinophil numbers in peripheral blood (C) in patients with AD. Journal of Allergy and Clinical Immunology 2001 107, 535-541DOI: (10.1067/mai.2001.113237) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Immunoreactive TARC was detected in the acute (a) and chronic (b) lesional skin of patients with AD and patients with psoriasis (d) . It was detectable in epidermal KCs, dermal endothelial cells, and infiltrating cells in lesional skin of patients with AD (b) . TARC was virtually negative in normal skin (c) and was weakly positive in epidermal KCs of psoriatic skin (d) . Ep, Epidermal KCs; E, endothelial cells; I, infiltrating cells (original magnification, 100×). Journal of Allergy and Clinical Immunology 2001 107, 535-541DOI: (10.1067/mai.2001.113237) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 4 CCR4 positivity of CD4+CD45RO+ cells in PBMCs of patients with AD (n = 10) was higher than that in healthy control subjects (n = 10) or patients with psoriasis (n = 10, a ). Representative data of FACS analysis are shown as follows: b , patients with AD; c , patients with psoriasis; d , healthy control subjects. Journal of Allergy and Clinical Immunology 2001 107, 535-541DOI: (10.1067/mai.2001.113237) Copyright © 2001 Mosby, Inc. Terms and Conditions