Sequence novelty among SSUnique pipeline-filtered OTUs (unclassified at the class level) in the Earth Microbiome Project (EMP) and Human Microbiome Project (HMP) data, identified by BLASTn search of a 10% random subset against nonredundant NCBI GenBank (excluding environmental and uncultured sequences). Sequence novelty among SSUnique pipeline-filtered OTUs (unclassified at the class level) in the Earth Microbiome Project (EMP) and Human Microbiome Project (HMP) data, identified by BLASTn search of a 10% random subset against nonredundant NCBI GenBank (excluding environmental and uncultured sequences). Asterisks correspond to mean sequence BLASTn identity. Michael D. J. Lynch, and Josh D. Neufeld mSystems 2016; doi:10.1128/mSystems.00133-16