David Bédard Méthot, MD, Évelyne Leblanc, MD, Yves Lacasse, MD  CHEST 

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Meta-analysis of Gastroesophageal Reflux Disease and Idiopathic Pulmonary Fibrosis  David Bédard Méthot, MD, Évelyne Leblanc, MD, Yves Lacasse, MD  CHEST  Volume 155, Issue 1, Pages 33-43 (January 2019) DOI: 10.1016/j.chest.2018.07.038 Copyright © 2018 American College of Chest Physicians Terms and Conditions

Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-analyses flow diagram. GERD = gastroesophageal reflux disease. CHEST 2019 155, 33-43DOI: (10.1016/j.chest.2018.07.038) Copyright © 2018 American College of Chest Physicians Terms and Conditions

Figure 2 Study of publication bias: funnel plot including all 18 case-control studies that met the inclusion criteria of the meta-analysis. CHEST 2019 155, 33-43DOI: (10.1016/j.chest.2018.07.038) Copyright © 2018 American College of Chest Physicians Terms and Conditions

Figure 3 Primary meta-analysis: association between GERD and IPF. IPF = idiopathic pulmonary fibrosis. See Figure 1 legend for expansion of other abbreviation. CHEST 2019 155, 33-43DOI: (10.1016/j.chest.2018.07.038) Copyright © 2018 American College of Chest Physicians Terms and Conditions

Figure 4 Meta-regression showing the relationship between the ratio of proportions of smokers and ex-smokers in case and control subjects and the measure of association between GERD and IPF reported in individual studies. See Figure 1 and 3 legends for expansion of abbreviations. CHEST 2019 155, 33-43DOI: (10.1016/j.chest.2018.07.038) Copyright © 2018 American College of Chest Physicians Terms and Conditions