Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome Carlos Moran, M.D.,

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Presentation transcript:

Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome Carlos Moran, M.D., M.Sc., Edgardo Garcia-Hernandez, M.D., M.Sc., Edgar Barahona, B.S., Sandra Gonzalez, B.S., Jose A Bermudez, M.D. Fertility and Sterility Volume 80, Issue 6, Pages 1466-1472 (December 2003) DOI: 10.1016/j.fertnstert.2003.05.010

FIGURE 1 The relationship between BMI and GIR in 32 patients with PCOS. There is a negative correlation between BMI and GIR, indicating greater insulin resistance as BMI increases. Moran. Insulin resistance and LH-FSH in PCOS. Fertil Steril 2003. Fertility and Sterility 2003 80, 1466-1472DOI: (10.1016/j.fertnstert.2003.05.010)

FIGURE 2 The relationship between WHR and GIR was observed in 32 patients with PCOS. A significantly negative correlation between body fat distribution and the GIR values was observed. Moran. Insulin resistance and LH-FSH in PCOS. Fertil Steril 2003. Fertility and Sterility 2003 80, 1466-1472DOI: (10.1016/j.fertnstert.2003.05.010)

FIGURE 3 Analysis of GIR in obese and nonobese PCOS patients during OGTT and GnRH test. The AUC for GIR was significantly lower (P<.03) in obese women than in nonobese women, both during OGTT and GnRH test. Symbols in left panel: filled triangle, nonobese GnRH; filled diamond, obese GnRH; open square, nonobese OGTT; filled square, obese OGTT. Right panel: open bars for AUC after GnRH and filled bars for AUC after OGTT. Moran. Insulin resistance and LH-FSH in PCOS. Fertil Steril 2003. Fertility and Sterility 2003 80, 1466-1472DOI: (10.1016/j.fertnstert.2003.05.010)

FIGURE 4 Analysis of LH-FSH ratio in obese and nonobese patients during oral glucose tolerance test (OGTT) and GnRH test. The AUC for LH-FSH ratio was similar in both groups during both OGTT and GnRH test. Symbols in the left panel: filled triangle, nonobese GnRH; filled diamond, obese GnRH; open square, nonobese OGTT; filled square, obese OGTT. Right panel: open bars for AUC after GnRH and filled bars for AUC after OGTT. Moran. Insulin resistance and LH-FSH in PCOS. Fertil Steril 2003. Fertility and Sterility 2003 80, 1466-1472DOI: (10.1016/j.fertnstert.2003.05.010)