Tomoregulin-1 improves cardiac morphology and function after pressure overload. Tomoregulin-1 improves cardiac morphology and function after pressure overload.

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Tomoregulin-1 improves cardiac morphology and function after pressure overload. Tomoregulin-1 improves cardiac morphology and function after pressure overload. Echocardiographic parameters of LVPWD (A), LV posterior wall at end-systole (LVPWS) (B), LV anterior wall at end-diastole (LVAWD) (C), LV anterior wall at end-systole (LVAWS) (D) and left ventricular percent fractional shortening (LVFS) (E) were analyzed in non-transgenic (NTG; n=55 and 28), tomoregulin-1-knockdown (n=33 and 14) and tomoregulin-1-overexpression (n=41 and 28) mice at 4 weeks after the sham and TAC operation (**P<0.01, ***P<0.001 versus NTG mice in sham group, #P<0.05, ###P<0.001 versus the percent change of NTG mice). (F) Heart-weight:body-weight ratio was calculated in NTG (n=18 and 12), tomoregulin-1-knockdown (n=10 and 8) and tomoregulin-1-overexpression (n=16 and 10) mice at 4 weeks after sham and TAC operation (&P<0.05 versus NTG mice). Dan Bao et al. Dis. Model. Mech. 2015;8:795-804 © 2015. Published by The Company of Biologists Ltd