Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

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Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload. H&E staining patterns of the whole-heart cross-sections from mice at 4 weeks after sham and TAC operation (A). Magnification of H&E-stained sections of the left ventricle (LV), showing disparate pathological changes (B). Magnification of Masson-trichrome-stained sections of LV; myocytes, stained red; collagenous tissue, stained green (C). The expression of Col3α1 was detected by real-time PCR, and the quantitative analysis of the expression of Col3α1 made using GAPDH for normalization (D; n=3 independent experiments, *P<0.05 versus NTG mice). NTG, non-transgenic. Dan Bao et al. Dis. Model. Mech. 2015;8:795-804 © 2015. Published by The Company of Biologists Ltd