Marla C. Dubinsky Clinical Gastroenterology and Hepatology

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Presentation transcript:

Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety Marla C. Dubinsky Clinical Gastroenterology and Hepatology Volume 2, Issue 9, Pages 731-743 (September 2004) DOI: 10.1016/S1542-3565(04)00344-1 Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 1 Thiopurine metabolism. Oral AZA is rapidly converted to 6-MP by a nonenzymatic process.19 Initial 6-MP transformations occur along competing catabolic (XO, xanthine oxidase; TPMT) and anabolic (HPRT, hypoxanthine phosphoribosyltransferase) enzymatic pathways. Once formed, 6-thiosine 5′-monophosphate (6-TImP) is further catalyzed by inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase (GMPS) and the di- and tri- derivatives of 6-thioguanosine 5′monophosphate (6-TGMP) formed by their respective kinases. 6-TU, 6-thiouric acid. Clinical Gastroenterology and Hepatology 2004 2, 731-743DOI: (10.1016/S1542-3565(04)00344-1) Copyright © 2004 American Gastroenterological Association Terms and Conditions