Proposed model whereby both CFH and CFHR5 are needed to prevent C3 accumulation along the glomerular basement membrane. Proposed model whereby both CFH.

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Academic Trainees Meeting – 5 th May, 2011 Interesting aspects of complement regulation…… Matthew Pickering Wellcome Trust Senior Fellow in Clinical Science.

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Proposed model whereby both CFH and CFHR5 are needed to prevent C3 accumulation along the glomerular basement membrane. Proposed model whereby both CFH and CFHR5 are needed to prevent C3 accumulation along the glomerular basement membrane. CFH deficiency (represented by white CFH protein) leads to C3 consumption and the production of C3 metabolites in plasma; these C3 metabolites then accumulate along the glomerular basement membrane (GBM). In CFHR5 nephropathy, abnormal CFHR5 (represented by white CFHR5 protein) results in defective regulation of C3 metabolites within the GBM. In this hypothetical model, we assume that CFHR5 but not CFH interacts directly with C3 metabolites in the kidney. Consequently, where C3 metabolites accumulate in the setting of CFH deficiency, we depict increased binding of CFHR5 in the kidney. Daniel P. Gale, and Matthew C. Pickering Dis. Model. Mech. 2011;4:721-726 © 2011. Published by The Company of Biologists Ltd