Expression of Shh-Gli target genes in astrocyte progenitors.

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Expression of Shh-Gli target genes in astrocyte progenitors. Expression of Shh-Gli target genes in astrocyte progenitors. (A-D″) Co-expression of β;-gal from the Gli1lacZ reporter line and Gli2 (A), Nkx6.1 (B), Pax6 (C) and S100 (D) at E15.5 in progenitors that will give rise to astrocytes. (A-D) β;-Gal; (A′-D′) marker; (A″-D″) merge; all with DAPI. (E,F) Gli1lacZ/+ expression is lost in ShhΔFP/ΔFP mutants. Dotted line indicates midline. (G-K″) Changes in Gli2, Pax6 and S100 expression in ShhΔFP/ΔFP and SmoΔNT/ΔNT embryos at E15.5 (G-I″) and E18.5 (J-K″). (L,M) Gfap expression (marking primarily fibrous astrocytes-FA) in WT and SmoΔNT/ΔNT mice at P26 in the gray matter region surrounding the central canal (boxed areas). (N) Quantification of Gfap expression in the gray matter in WT and SmoΔNT/ΔNT mice. Error bars indicate s.e.m. Scale bars: 100 μm. Kwanha Yu et al. Development 2013;140:1594-1604 © 2013. Published by The Company of Biologists Ltd