Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer. Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer.

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Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer. Expression of RUNX2 correlates with ER/PR/HER2-negative human breast cancer. Invasive breast carcinomas from a tumour tissue microarray (TMA-1) were stained for RUNX2. (A) Scatterplot showing the range of positive histoscores. Expression was divided into RUNX2-negative (histoscore 0), -low (histoscore 1–24) or -high (histoscore ≥25) in 416 breast cancers. The dotted line at histoscore 25 demonstrates the cut-off for RUNX2-high patients. Position on the y-axis reflects the order in which samples were analysed. (B) Kaplan-Meier of patient survival for 384 patients in A for which follow-up data was available. Survival is plotted for patients with high-RUNX2 tumours (n=21) and negative/low-RUNX2 tumours (n=363). (C) Examples of individual tumours stained for RUNX2 and ER, depicting the reciprocal expression pattern. Boxed areas are shown at higher magnification. (D) Significantly more RUNX2-high cancers were ER-negative (P=0.005; chi-square) and specifically associated with the triple-negative (ER/PR/HER2-negative) group (P=0.008; chi-square). Laura McDonald et al. Dis. Model. Mech. 2014;7:525-534 © 2014. Published by The Company of Biologists Ltd