Tbx1 regulates the Mef2c AHF enhancer in vivo.

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Tbx1 regulates the Mef2c AHF enhancer in vivo. Tbx1 regulates the Mef2c AHF enhancer in vivo. (A-E) Immunofluorescence of transverse sections of E9.5 (20 somites) embryos with the genotype indicated, using anti-Cre (green) and anti-Isl1 (red) antibodies. The first row of sections (A) corresponds to a level immediately below the outflow tract. The second row (B) is just anteriorly to the inflow tract, while the third fourth and fifth rows (C-E) correspond to the inflow tract. Note that the Cre signals in A and B are comparable in the three genotypes, while in C-E, reduced dosage of Tbx1 is associated with expansion of Cre expression (dashed line arrows). We examined three embryos per genotype. Fig. S3 shows Tbx1 gene expression in similar sections. A, atrium; DPW, dorsal pericardial wall (line arrowhead); IFT, inflow tract; NT, neural tube; OFT, outflow tract; Ph, pharynx. Scale bar: 100 μm. Luna Simona Pane et al. Dis. Model. Mech. 2018;11:dmm029967 © 2018. Published by The Company of Biologists Ltd