Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis Stefan Fischer,

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Presentation transcript:

Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis Stefan Fischer, MD, MSc, Marc de Perrot, MD, MSc, Mingyao Liu, MD, Alexandra A MacLean, MD, Jonathan A Cardella, MSc, Yumiko Imai, MD, Michiharu Suga, MD, Shaf Keshavjee, MD, MSc, FRCSC, FACS The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 4, Pages 1174-1180 (October 2003) DOI: 10.1016/S0022-5223(03)00114-4

Figure 1 In vivo transtracheal adenoviral mediated IL-10 gene transfection of donor lungs improves posttransplant lung function. Study groups: EV, empty vector; VD, vector diluent; IL-10, adenovirus-mediated interleukin-10. *P = .0001 versus other groups. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1174-1180DOI: (10.1016/S0022-5223(03)00114-4)

Figure 2 IL-10 in vivo donor lung transfection leads to a switch from necrosis to apoptosis in transplanted and reperfused lungs. Note that the total number of dead cells is similar in all groups, but that the AdIL-10 group has significantly less necrosis and more apoptosis (*P = .0001; #P = .01) compared with the other groups. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1174-1180DOI: (10.1016/S0022-5223(03)00114-4)