Raptiva efalizumab Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons.

Slides:

Advertisements

Similar presentations

Immunology Overview. Innate vs Acquired Immunity Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms –Fever –Inflammation –Complement.

Advertisements

Monoclonal Antibodies Large scale production and their implications in AIDS research.

MONOCLONAL ANTIBODIES

Lec 16 Medical biotechnology Shah Rukh Abbas, PhD

SAR650984, a CD38 Monoclonal Antibody in Patients with Selected CD38+ Hematological Malignancies — Data from a Dose-Escalation Phase I Study Martin TG.

T cell and B cell activation For Ab production against Antigens.

MLRS 242 Immunology Pat Reed Antibodies

Monoclonal Antibodies Dr. Aws Alshamsan Department of Pharmaceutics Office: AA87 Tel:

C-BR- 1 Raptiva ™ (efalizumab) Benefit:Risk Assessment Charles Johnson, MB, ChB Senior Director Head of Specialty Biotherapeutics Genentech, Inc.

C-IN- 1 Raptiva ™ (efalizumab) Introduction Michelle Rohrer, PhD Director Regulatory Affairs Genentech, Inc.

MOLECULAR BASIS OF ANTIGEN RECOGNITION BY B CELLS AND ANTIBODIES.

Antibodies. Properties and functions of the immunoglobulins

Biological Therapies for Psoriasis Carle Paul, Dermatology, Purpan Hospital, Toulouse International Psoriasis Day, October 2006.

1 C-MOA- Efalizumab Mechanism of Action and Dose Determination Charles Johnson, MB, ChB Senior Director Head of Specialty Biotherapeutics Genentech, Inc.

Lab 6 Ig Purification What will the Ig be used for? How pure does it need to be? What is the source of the antibody (serum, ascites, cell culture supernatant)

(Approved investigational)

Omalizumab Drugbank ID : DB00043

I am in the Biotechnology industry

Alteplase Drugbank ID : DB00009 Protein chemical formula :

ELISA for mAb detection and Quantification

Subcutaneous injection

Alemtuzumab (DB00087) Approved and Investigational Drug

Ramucirumab Protein chemical formula : C6374H9864N1692O1996S46

RAXIBACUMAB DB08902 C6320H9794N1702O1998S kDa CATEGORY

Drugbank ID : DB00005 Half life : 102 +/- 30 hrs

Natalizumab (Approved, Investigational)

Vedolizumab Protein chemical formula : C6528H10072N1732O2042S42

Monoclonal antibodies and fusion proteins in medicine

MOnoclonal antibodies and potential applications in migraine

Ibritumomab(DB00078) Approved Drug

Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells Mouldy Sioud,

Antibody Drug Conjugates Services Antibody-drug conjugates Antibody-drug conjugates (ADCs) are a very important class of highly potent drugs designed as.

In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections Chasity D. Andrews,

Mammalian Cell Expression Profacgen. Mammalian cell expression systems are the best choice for the production of eukaryotic proteins, especially when.

Ixekizumab Drugbank ID : DB11569 Molecular Weight (Daltons) :146,158

Anti-therapeutic antibodies Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer.

Rabbit antibodies Creative Biolabs is a pioneer in recombinant monoclonal antibody development and manufacture. Specifically, we have a wide range of specific.

Therapeutic antibodies Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer a.

Anti-therapeutic antibodies Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer.

Chicken igy Creative Biolabs is a professional manufacturer of chicken IgY antibodies and provides the most cost-effective chicken IgY antibody products.

Mouse antibody Creative Biolabs offers the unique native mouse monoclonal antibody discovery service for producing custom monoclonal antibodies by our.

Human antibody discovery Based on the technology of B cell sorting, Creative Biolabs provides Native™ human antibody discovery service to generate native.

Molecular targeted therapies in hepatocellular carcinoma: From pre-clinical models to clinical trials Pippa Newell, Augusto Villanueva, Josep M. Llovet

Antibodies (Immunoglobulins)

Journal of Allergy and Clinical Immunology

Program Introduction. Monoclonal Antibodies and Immunogenicity: Relevance to Clinical Practice?

Demystifying the Science of Monoclonal Antibodies in Migraine

Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation by Eric Boilard, Guillaume Paré, Matthieu Rousseau, Nathalie.

Anti-integrin therapy in inflammatory bowel disease

Generation of new peptide-Fc fusion proteins that mediate antibody-dependent cellular cytotoxicity against different types of cancer cells Mouldy Sioud,

Effect of Therapeutic Integrin (CD11a) Blockade with Efalizumab on Immune Responses to Model Antigens in Humans: Results of a Randomized, Single Blind.

Biological Therapies for Inflammatory Bowel Diseases

Diagnostic and Therapeutic Evaluation of an Anti-Langerhans Cell Histiocytosis Monoclonal Antibody (NA1/34) in a New Xenograft Model Samuel Murray, Jenny.

The Rising Cost of Healthcare and Potential Impact of Biosimilars

Obiltoxaximab Drugbank ID :DB05336 Molecular Weight (Daltons) :148000

Rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through αvβ3 integrin engagement Y. Bechah, C. Capo, G. Grau, D. Raoult,

Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness Emma Guttman-Yassky, Yulia Vugmeyster, Michelle.

In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections Chasity D. Andrews,

T exosomes bind MAdCAM-1 via RA-increased integrin α4β7.

TGFβ Inhibits CD1d Expression on Dendritic Cells

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation.

Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts Bryce D Beseth, MD, Robert B Cameron, MD, Pamela Leland,

PAX8 (mAb) immunohistochemistry in POMTs, eMOMCs and ePMCs.

Elevated levels of tRNAiMet promote α5β1-dependent cell migration

US Army Medical Research and Materiel Command

US Army Medical Research and Materiel Command

Transforming growth factor β1 increases fibronectin deposition through integrin receptor α5β1 on human airway smooth muscle Lyn M. Moir, PhD, Janette.

Presentation transcript:

raptiva efalizumab Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.

Datasheet Specifications ClassifyProtein therapeutics that interfere with a molecule or organism: Immunoregulation TherapeuticEfalizumab Trade NameRaptiva FunctionHumanized mAb directed against cD11a Examples of Clinical UseAdults with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy References SynonymsAnti alphaL integrin, antiCD11 alpha, hu1124, Raptiva For lab research use only, not for diagnostic, therapeutic or any in vivo human use. Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us