Non-competitive antagonism

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Presentation transcript:

Non-competitive antagonism can be confused with insurmountable competitive antagonism differs in that antagonist and agonist are not competing for the same site eg Ca channel blocker - VERAPAMIL could be PHYSIOLOGICAL antagonists ie have opposing effects eg on blood pressure HISTAMINE & NORADRENALINE

Other forms of antagonism PARTIAL AGONISTS Since partial agonists cannot produce a maximum response They inhibit a full agonist from doing so PHYSIOLOGICAL ANTAGONISTS ie have opposing effects eg on blood pressure HISTAMINE & NORADRENALINE

Other forms of antagonism II CHEMICAL uncommon a substance which combines with the agonist in solution PHARMACOKINETIC antagonist “reduces” the amount of drug eg WARFARIN & BARBITURATES barbiturates induce hepatic metabolism hence warfarin broken down more quickly than expected

Recommended Reading Antagonism Medical Pharmacology at a Glance, 5th Ed: Page 11 Pharmacology, 5th Ed: Pages 12-14 & 18-19 Basic and Clinical Pharmacology Online Book: Section I, Chapter 2, Relation between drug concentration and response, other mechanisms of drug antagonism