Surrin S. Deen, Frank Riemer, Mary A. McLean, Andrew B. Gill, Joshua D

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Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer Surrin S. Deen, Frank Riemer, Mary A. McLean, Andrew B. Gill, Joshua D. Kaggie, James T. Grist, Robin Crawford, John Latimer, Peter Baldwin, Helena M. Earl, Christine A. Parkinson, Sarah A. Smith, Charlotte Hodgkin, Elizabeth Moore, Mercedes Jimenez-Linan, Cara R. Brodie, Helen C. Addley, Susan J. Freeman, Penelope L. Moyle, Evis Sala, Martin J. Graves, James D. Brenton, Ferdia A. Gallagher European Journal of Radiology Open Volume 6, Pages 156-162 (January 2019) DOI: 10.1016/j.ejro.2019.04.001 Copyright © 2019 The Authors Terms and Conditions

Fig. 1 73-year old high grade serous ovarian cancer patient. P1 and P2 represent slices through the two sodium phantoms. The green outline shows a peritoneal cancer deposit. (A) T2-weighted image. (B) Sodium B1 map, scale bar represents arbitrary units. (C) Total sodium image; scale bar represents image intensity. (D) Intracellular weighted sodium image; scale bar represents image intensity. (E) Masked total sodium concentration map; scale bar represents sodium concentration in mM. (F) Masked intracellular weighted sodium concentration map, scale bar represents sodium concentration in mM. (G) Fused T2W image and total sodium concentration map. (H) Fused T2W image and intracellular weighted sodium concentration map. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article). European Journal of Radiology Open 2019 6, 156-162DOI: (10.1016/j.ejro.2019.04.001) Copyright © 2019 The Authors Terms and Conditions

Fig. 2 Box plots showing the spread of TSC (total sodium concentration) and IWS (intracellular weighted sodium) values for cancer and muscle. European Journal of Radiology Open 2019 6, 156-162DOI: (10.1016/j.ejro.2019.04.001) Copyright © 2019 The Authors Terms and Conditions

Fig. 3 Tumour tissue from a 73-year old high grade serous ovarian cancer patient; (A) 1x magnification haematoxylin stained slide of tumour tissue; (B) automated cell segmentation used for cell counting. Scatterplots of; (C) tissue sodium concentration against cellularity, (D) intracellular weighted sodium concentration against cellularity. European Journal of Radiology Open 2019 6, 156-162DOI: (10.1016/j.ejro.2019.04.001) Copyright © 2019 The Authors Terms and Conditions