BAP1 deficiency results in thymic atrophy and loss of thymocyte populations. BAP1 deficiency results in thymic atrophy and loss of thymocyte populations.

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BAP1 deficiency results in thymic atrophy and loss of thymocyte populations. BAP1 deficiency results in thymic atrophy and loss of thymocyte populations. (A and B) Thymi (A) and hematoxylin and eosin staining of thymi (B) from Bap1fl/flRosa26CreERT2 and Bap1wt/wtRosa26CreERT2 mice 2.5 weeks after tamoxifen treatment. (C) Thymocyte numbers in Bap1fl/flRosa26CreERT2 and Bap1wt/wtRosa26CreERT2 mice 1 week after tamoxifen treatment (n = 6 to 7). (D) Cell numbers of the indicated thymocyte populations in Bap1fl/flRosa26CreERT2 and Bap1wt/wtRosa26CreERT2 mice 1 week after tamoxifen treatment, as determined by flow cytometry analysis. All data are representative of at least three independent experiments. For (C) and (D), each symbol represents an individual mouse and the line shows the median. *P < 0.05, **P < 0.01, ****P < 0.0001 based on unpaired Student’s t test. Teresita L. Arenzana et al. Sci. Immunol. 2018;3:eaal1953 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works