Oncologist-Directed Solutions for Cancer Therapy & Drug Discovery CERTIS ONCOLOGY SOLUTIONS Oncologist-Directed Solutions for Cancer Therapy & Drug Discovery Privileged & Confidential Do not distribute without permission Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 Our Mission Our Mission Certis Oncology Solutions was formed in 2016 with the mission to provide individualized precision patient care. Our patient-directed therapy enables oncologists to tailor and optimize therapies for patients suffering from aggressive cancers. We also provide pre-clinical services for pharmaceutical and biotech companies. The differentiators for all of our services are the Certis Orthotopic PDX techniques. Copyright © Certis Oncology Solutions, 2019
Highest Establishment Rates are in Untreated HG Tumors Our Mission Highest Establishment Rates are in Untreated HG Tumors Prior Treatment Negatively Correlates with Xenograftability Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 Clinical Concordance Our Mission Copyright © Certis Oncology Solutions, 2019
PDX In Vivo Pharmacology Studies to Direct Clinical Management Our Mission Copyright © Certis Oncology Solutions, 2019
Over 300 Tumors Received and 40 Publications Our Mission https://certisoncology.com/recently-published/ Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 CLIA Certified Our Mission November 2017 – Submitted May 2018 – Registered March 2019 – Passed On-site inspection Zero deficiencies Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 Available PDX Models Operations PDX Number Indication Category PDX259 Triple Negative Breast Breast PDX256 Colorectal (Liver Metastasis) Colon PDX264 Colorectal PDX278 PDX287 PDX296 PDX304 PDX292 Gastric PDX295 Lung (Hip Metastasis) Lung PDX024 Melanoma PDX132 PDX134 PDX148 PDX001 Undifferentiated Pleomorphic Sarcoma Sarcoma PDX011 Follicular Dendridic Sarcoma PDX025 Liposarcoma PDX061 Pleomorphic sarcoma with rhabdomyosarcomatous differentiation PDX064 Pleomorphic liposarcoma PDX077 Pleomorphic Sarcoma PDX103 Leiomyosarcoma PDX172 Mxyofibrosarcoma PDX210 Osteosarcoma PDX257 Ewing's Sarcoma PDX261 Recurrent Liposarcoma PDX263 PDX265 PDX276 Radiation-associated Sarcoma PDX288 Copyright © Certis Oncology Solutions, 2019
Triple Negative Breast PDX Operations 58F BRCA1+ with untreated left breast mass. Invasive ductal carcinoma, grade 3, PR-, ER weak positive, HER2 IHC equivocal. Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 Ewing’s Sarcoma PDX Operations 63M Ewing’s Sarcoma from right humerus EWSR1-FLI1 Fusion Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 In Vivo Pharmacology – PDX257 Ewing’s Sarcoma Operations Confidential Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 Colorectal PDX Operations 39 M – colorectal carcinoma from liver metastasis 14 gauge core needle biopsy from liver Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 PDX278 – CRC Liver Met Operations Day 1 Day 15 Copyright © Certis Oncology Solutions, 2019
Copyright © Certis Oncology Solutions, 2019 PDX278 – CRC Liver Met Operations Primary Implant Vasculature Primary Implant Copyright © Certis Oncology Solutions, 2019
Models in Development Operations PDX Indication Category PDX Squamous Cell Carcinoma Skin PDX012 Leiomyosarcoma Sarcoma PDX031 PDX038 PDX039 PDX043 PDX103 PDX120 PDX173 PDX181 PDX007 Myxofibrosarcoma PDX042 Spindle Cell Sarcoma PDX034 GIST PDX010 PDX017 PDX018 NOS PDX020 PDX028 UPS PDX059 PDX061 Pleomorphic sarcoma with rhabdomyosarcomatous differentiation PDX073 PDX077 HG Pleomorphic Sarcoma w Myogenic differentiation PDX093 Osteosarcoma PDX117 Chordoma PDX149 Non Otherwise Specified Sarcoma PDX167 Metastatic Carcinoma PDX138 PDX143 Chondrosarcoma, de-differentiated, grade 3 PDX150 PDX172 PDX174 Metastatic Osteosarcoma PDX183 PDX202 Malignant Peripheral Nerve Sheath PDX009 Well-diff/de-diff Liposarcoma PDX045 PDX055 Pleomorphic Liposarcoma Carcinoma PDX083 Dediff Liposarcoma PDX108 Myxoid Liposarcoma PDX Indication Category PDX158 Dediff Liposarcoma Sarcoma PDX188 Well Diff Liposarcoma PDX165 Intramuscular myxoma PDX008 Ewing's Sarcoma PDX206 PDX025 PDX054 Well-diff/de-diff Liposarcoma PDX064 Pleomorphic Liposarcoma PDX142 PDX177 PDX190 Liposarcoma PDX193 PDX199 SD-Mry PDX109 Synovial Sarcoma PDX205 Undifferentiated Pleomorphic Sarcoma PDX211 Spindle Cell Sarcoma PDX169 NOS malignant undifferentiated small round blue cell neoplasm PDX203 Non Otherwise Specified Sarcoma PDX-Bsarc Sarcoma Sarcoma SD031 Pancreatic (metastatic) Pancreatic MDA AC2 MDA AC5 PTAX39 PTAX52 PTAX70 AA-316 PDX063 Melanoma PDX107 PDX160 Metastatic Melanoma SD032 Gastric Carcinoma Gastric 274BMC Colorectal CT1 SD034 SD039 Colon Adenocarcinoma Carcinoma SD058 SD062 Cce
Copyright © Certis Oncology Solutions, 2019 Newly Acquired Models Operations Glioblastoma Pancreatic Colorectal Ovarian Breast Lung Melanoma Copyright © Certis Oncology Solutions, 2019