NLRP3 inflammasome is activated during infectious exacerbations of chronic obstructive pulmonary disease (ECOPD). a) Protein concentration of caspase-1,

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Presentation transcript:

NLRP3 inflammasome is activated during infectious exacerbations of chronic obstructive pulmonary disease (ECOPD). a) Protein concentration of caspase-1, interleukin (IL)-1β and IL-18 in sputum of COPD patients studied during an ECOPD (V1) and at recovery (V... NLRP3 inflammasome is activated during infectious exacerbations of chronic obstructive pulmonary disease (ECOPD). a) Protein concentration of caspase-1, interleukin (IL)-1β and IL-18 in sputum of COPD patients studied during an ECOPD (V1) and at recovery (V2). Data are presented as mean±sem of n=41 (V1) and n=41 (V2). b) Sputum concentrations of caspase-1, IL-1β and IL-18 in COPD patients studied during an episode of ECOPD of infectious or noninfectious origin. Data are presented as mean±sem of n=17 infectious V1 (during ECOPD), n=14 infectious V2 (recovery), n=30 noninfectious V1 and n=21 noninfectious V2 individuals. *: p<0.05; **: p<0.01. c) Representative Western blot for ASC sputum samples from ECOPD patients, denoting oligomeric ASC complexes, a hallmark of inflammasome activation. ASC oligomeric complexes were not detected when samples were run under reduced conditions. MK: marker. Rosa Faner et al. ERJ Open Res 2016;2:00002-2016 ©2016 by European Respiratory Society