Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy.

Slides:

Advertisements

Similar presentations

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy Erik Wambre, PhD, Jonathan.

Advertisements

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

Treg and Teff cell subsets show increased TCR overlap during colitis.

MP cells are generated from naïve cells in the periphery.

Longitudinal analysis of cross-group HA stem–binding lineages.

FIP200 deficiency alters mitochondria activation and ROS production in T cells. FIP200 deficiency alters mitochondria activation and ROS production in.

Three different types of transfer functions with a codomain of [0,1].

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy Erik Wambre, PhD, Jonathan.

VH usage of cross-reactive B cells induced by H5N1 or H7N9 vaccination

MP cells consist of rapidly proliferating CD5hi and relatively quiescent CD5lo cells, both of which require CD28 signaling for Ki67 expression. MP cells.

Tfr cells robustly secrete IL-10 after acute viral infection.

Donor and recipient BAL T cells are phenotypically and functionally memory T cells. Donor and recipient BAL T cells are phenotypically and functionally.

Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.

Fig. 7 Correlation of NHP and human ISGs.

Blood Tfr cells show expression of follicular and regulatory markers.

T-bethi MP cells produce IFN-γ in response to IL-12.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Blood Tfr cells are indicators of ongoing humoral activity.

Online verification using reachable occupancies.

MP cells are generated from naïve cells in the periphery.

Fig. 4 Labeling of Msmeg with DMN-Tre is fast and specific and depends on Ag85A function. Labeling of Msmeg with DMN-Tre is fast and specific and depends.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fig. 1. MSCs undergo in vivo apoptosis after infusion without affecting immunosuppression. MSCs undergo in vivo apoptosis after infusion without affecting.

Fig. 7 Bacterial dependency networks in IgA deficiency and HDs.

Fig. 5 A competent Fc is required for the antitumor immune response.

Fig. 2 Preserved long-term functionality of the TEHVs over 1-year follow-up as assessed by ICE and cardiac MRI flow measurements. Preserved long-term functionality.

Evaluation of multidonor class Ig sequences obtained from H5N1 and H7N9 vaccinated donors. Evaluation of multidonor class Ig sequences obtained from H5N1.

CD4-TEMRA cells are heterogeneous across donors.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

In vivo release of doxycycline hyclate from the GRS in a swine model

CD4+CLA+CD103+ T cells in skin and blood are clonally related.

Fig. 4 Deorphanization of quinine and mefloquine protein targets.

Fig. 5. In vivo characterization of adipogenesis by CT.

CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)

Fig. 2 Reference-fixing experiment, results.

RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development. RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development.

CD4+CLA+CD103+T cells from human blood and skin share a functional profile. CD4+CLA+CD103+T cells from human blood and skin share a functional profile.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded.

MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. MR1Ts recognized by the hpMR1+EC tetramer are more likely to be TRAV1-2−. PBMCs.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion.

Fig. 1. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy.

Fig. 3 BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS blocks functional responses in primary immune.

Fig. 2 In situ vaccination of CpG in combination with anti-OX40 antibody cures established local and distant tumors. In situ vaccination of CpG in combination.

BMS blocks functional responses in primary immune cells driven by IFNα

AEGIS autonomous targeting process.

Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.

CD25 expression predicts effector and memory differentiation.

Fig. 1 Crohn’s disease association within the LRRK2 locus.

SLC30A8 and INS gene expression in mTECs and circulating islet-reactive CD8+ T cell frequencies in HLA-A2+ and HLA-A2− healthy donors. SLC30A8 and INS.

Fig. 2 Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes in cognition. Effect of CSF sTREM2– and CSF sTREM2–to–p-tau181 ratio on changes.

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders by Erik Wambre, Veronique Bajzik, Jonathan.

Fig. 2 Isopropanol-tolerant E. faecium resists disinfection.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 5 The regulatory and functional properties of RECs.

Fig. 2 Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. Neonatal ZIKV.

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Fig. 5. High burdens of AA signature mutations and predicted immunogenicity in Taiwan HCCs. High burdens of AA signature mutations and predicted immunogenicity.

Effects of highly concentrated SFN provided as BSE in T2D patients

Fig. 7 BEL immune response.

Fig. 1 Isopropanol tolerance variation among E. faecium isolates.

Fig. 4 Gallium increases P. aeruginosa sensitivity to peroxides.

Fetal-derived γδ T cells infiltrate the meninges from birth.

Fig. 8 Immune correlates of protection.

Fig. 2. Cellular response to FolamiRs in vitro.

Presentation transcript:

Fig. 4. Peanut-specific TH2A cells are specifically targeted during immunotherapy. Peanut-specific TH2A cells are specifically targeted during immunotherapy. (A) Ex vivo phenotype of peanut-reactive CD4+ T cells before and after DBPCFC with peanut flour. Each dot represents a single donor. (B) Ex vivo frequency of peanut-reactive CD4+ T cells before and after DBPCFC. (C) Plots show representative ex vivo profile of peanut-reactive CD4+ T cells according to CD27, CD161, and CRTH2 expression before and after CODIT both in placebo and active groups. Data are representative of at least three donors per group. Percentages of CD27− allergen-specific T cells expressing the given marker are indicated in the upper left quadrant. (D) Ex vivo peanut-specific TH2A cell frequencies before and after CODIT both in placebo (n = 3) and active (n = 4) groups. Differences between groups were analyzed by using the Wilcoxon matched pairs test (A and B) and unpaired t test (D). *P < 0.05. Erik Wambre et al., Sci Transl Med 2017;9:eaam9171 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works