Figure 1 Volcano plot Peptides (n = 2,260) showing distribution of fold change and statistical significance. Volcano plot Peptides (n = 2,260) showing.

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Figure 1 Volcano plot Peptides (n = 2,260) showing distribution of fold change and statistical significance. Volcano plot Peptides (n = 2,260) showing distribution of fold change and statistical significance. In this plot, each point represents a peptide and shows the ratio between CSF samples of children with multiple sclerosis (MS) (n = 18) and samples of children with monophasic acquire demyelinating syndromes (ADS) (n = 21) plotted against the level of statistical significance. Y-axis shows p values obtained (plotted at log10) from a Wilcoxon test performed between abundances of peptides. X-axis shows the ratio of the median between MS and monophasic ADS samples (plotted on log2). (A) Above the dashed horizontal line, red points (n = 53 peptides) were found with increased abundance (right side of the vertical line) and green points (n = 35 peptides) with decreased abundance (left side of the vertical line) in the MS group (compared to the monophasic ADS group). (B) Peptides shown in gray below the dashed horizontal line did not pass the stringent statistical criteria for identification of a candidate peptide. Vaibhav Singh et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e155 © 2015 American Academy of Neurology