Pei-Song Gao, MD, PhD, Nicholas M

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The Editors’ Choice Journal of Allergy and Clinical Immunology

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Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum Pei-Song Gao, MD, PhD, Nicholas M. Rafaels, MS, Tracey Hand, MSc, Tanda Murray, MHS, Mark Boguniewicz, MD, Tissa Hata, MD, Lynda Schneider, MD, Jon M. Hanifin, MD, Richard L. Gallo, MD, Li Gao, MD, PhD, Terri H. Beaty, PhD, Lisa A. Beck, MD, Kathleen C. Barnes, PhD, Donald Y.M. Leung, MD Journal of Allergy and Clinical Immunology Volume 124, Issue 3, Pages 507-513.e7 (September 2009) DOI: 10.1016/j.jaci.2009.07.034 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Summary of association tests among European American subjects showing significance for each FLG mutation. The –log10-transformed P values on the y axis for all genotyped markers are plotted against their genomic position in NCBI Build 35 in megabase along the x axis. Red circles indicate associations for ADEH; green circles indicate associations for AD. The horizontal dotted line indicates nominal significance at P < .05. Journal of Allergy and Clinical Immunology 2009 124, 507-513.e7DOI: (10.1016/j.jaci.2009.07.034) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Triangle plots showing estimated admixture in 2 populations Triangle plots showing estimated admixture in 2 populations. Admixture estimates were generated using 74 AIMs in STRUCTURE (v2.2; http://pritch.bsd.uchicago.edu/software). The International HapMap Project (http://www.hapmap.org) samples (or 60 Yoruba [YRI], 60 Utah European American [CEU], 90 Han Chinese/Tokyo Japanese [CHB/JPT] founders) were used as reference populations. A, A total of 176 African American AD patients (pink circles) and 152 nonatopic controls (yellow circles) compared with 60 YRI (red circles), 60 CEU (green circles), and 90 CHB/JPT (blue circles) founders. B, A total of 241 European American AD patients (pink circles) and 153 nonatopic controls (yellow circles) compared with 60 YRI (red circles), 60 CEU (green circles), and 90 CHB/JPT (blue circles) founders. Journal of Allergy and Clinical Immunology 2009 124, 507-513.e7DOI: (10.1016/j.jaci.2009.07.034) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Gene structure and LD estimation for 11 FLG variants spanning 33 Gene structure and LD estimation for 11 FLG variants spanning 33.3 kb on chromosome 1q31. The value within each diamond is the pairwise r2 statistic in 432 European American founders (A) and 339 African American founders (B). Diamonds without a number correspond to D' = 1; shading represents the magnitude and significance of pairwise LD with a red to white gradient reflecting higher to lower LD values (http://www.broad.mit.edu/haploview). The middle panel shows the FLG gene structure, with exons in pink and introns in light gray. Journal of Allergy and Clinical Immunology 2009 124, 507-513.e7DOI: (10.1016/j.jaci.2009.07.034) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Summary of association tests between FLG haplotypes and AD and the subphenotype, ADEH. PLINK results showing P values from haplotypes constructed across sliding windows of sizes 2 to 4 for subjects (A) with AD versus controls and ADEH-positive subjects (B) versus ADEH-negative subjects in European Americans. P value of the test is represented by the color of the box, and the color coding of P values is as presented in the figure. Journal of Allergy and Clinical Immunology 2009 124, 507-513.e7DOI: (10.1016/j.jaci.2009.07.034) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions