Urine cartilage oligomeric matrix protein (COMP) measurement is useful in discriminating the osteoarthritic Thoroughbreds K. Misumi, Ph.D., M. Tagami,

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Urine cartilage oligomeric matrix protein (COMP) measurement is useful in discriminating the osteoarthritic Thoroughbreds K. Misumi, Ph.D., M. Tagami, D.V.M., T. Kamimura, D.V.M., D. Miyakoshi, D.V.M., I.E. Helal, D.V.M., K. Arai, D.V.M., M. Fujiki, Ph.D. Osteoarthritis and Cartilage Volume 14, Issue 11, Pages 1174-1180 (November 2006) DOI: 10.1016/j.joca.2006.04.017 Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Immunoblot analysis of urine using mAb 14G4 and AP reaction; mAb 14G4 bound to fragments of equine COMP in urine. The sizes of the positive bands were determined to be approximately 150, 100, and 60kDa. Osteoarthritis and Cartilage 2006 14, 1174-1180DOI: (10.1016/j.joca.2006.04.017) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Inhibition curves of COMP in urine. The linear portion of the curve obtained by dilution of horse urine (dilution ratio between 0.5 and 0.03125) paralleled that of the standard curve obtained using purified COMP (between 0.8 and 6.75μg of equine cartilage COMP/ml) and mAb 14G4. Osteoarthritis and Cartilage 2006 14, 1174-1180DOI: (10.1016/j.joca.2006.04.017) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 COMP concentration in urine from control and diseased horses. Urinary COMP levels in horses with AJD (including fractures and OC) and SJD were significantly higher than those in the controls. Osteoarthritis and Cartilage 2006 14, 1174-1180DOI: (10.1016/j.joca.2006.04.017) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Relationship of measured COMP levels among urine, SF, and serum samples from diseased horses. There was a significant negative logarithmic correlation between the urinary and SF COMP levels in horses with fracture, but no significant correlation between OC and SJD cases. Osteoarthritis and Cartilage 2006 14, 1174-1180DOI: (10.1016/j.joca.2006.04.017) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Correlation of urinary COMP levels with MMP-2 and -9 activities in SF from horses with fracture. The urinary COMP levels were positively correlated with MMP-2 and -9 activities. Osteoarthritis and Cartilage 2006 14, 1174-1180DOI: (10.1016/j.joca.2006.04.017) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions