The potential and limitations of cartilage-specific (V+C)− fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine.

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Presentation transcript:

The potential and limitations of cartilage-specific (V+C)− fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid Michele A. Steffey, D.V.M., Naoki Miura, D.V.M., Ph.D., Rory J. Todhunter, B.V.Sc., Ph.D., Stephanie G. Nykamp, D.V.M., Kathleen P. Freeman, D.V.M., Ph.D., Virginia Scarpino, M.A., Margaret A. Vernier-Singer, B.S., Hollis N. Erb, D.V.M., Ph.D., James N. MacLeod, V.M.D., Ph.D., George Lust, Ph.D., Nancy Burton-Wurster, Ph.D. Osteoarthritis and Cartilage Volume 12, Issue 10, Pages 818-825 (October 2004) DOI: 10.1016/j.joca.2004.07.002 Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Schema of dog populations used in this study. The shaded boxes correspond to the groups identified in Tables I and II. Osteoarthritis and Cartilage 2004 12, 818-825DOI: (10.1016/j.joca.2004.07.002) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 COMP and (V+C)− fibronectin in synovial fluid in response to CCL deficiency. Synovial fluid samples were collected and analyzed for COMP (A) and for (V+C)− fibronectin (B) as described in Materials and methods. Although the data show considerable overlap among individuals (as can be visualized in these box and whisker plots, indicating medians, 25th and 75th percentiles) both COMP and (V+C)− fibronectin concentrations were significantly elevated in synovial fluid from the contralateral knees relative to affected knees (P=0.003) and to knees from control dogs (P=0.04 and P=0.03, respectively). * indicates possible outliers. Osteoarthritis and Cartilage 2004 12, 818-825DOI: (10.1016/j.joca.2004.07.002) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Radiographic scores for clinic patients. Lateral and cranio-caudal radiographs were performed on all clinical patients and scored as described in Materials and methods. Scores were higher in the affected stifles in almost all cases; nevertheless, the highest score was less than 8 out of a possible total of 21. Osteoarthritis and Cartilage 2004 12, 818-825DOI: (10.1016/j.joca.2004.07.002) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions