Figure 1 Effect of Ang II treatment for 4 weeks on aortic IL-12p35 expression. (A) IL-12p35 levels were measured in ... Figure 1 Effect of Ang II treatment.

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Figure 1 Effect of Ang II treatment for 4 weeks on aortic IL-12p35 expression. (A) IL-12p35 levels were measured in ... Figure 1 Effect of Ang II treatment for 4 weeks on aortic IL-12p35 expression. (A) IL-12p35 levels were measured in saline-infused and Ang II-infused mice by western blot analysis (t-test). (B) Immunofluorescence analysis of IL-12p35 protein expression in aortas in each group (×200). (C) Effect of Ang II treatment on IL-12p35 mRNA expression in Mø, B lymphocytes, T lymphocytes, and DCs (t-test). (D) Double immunofluorescence staining of anti-F4/80 and anti-IL-12p35 in Ang II-infused mice (×400). N = 6 in each group. *P < 0.05 vs. the saline group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 SBP and HR of angiotensin II-infused mice were measured using a tail-cuff. (A) SBP was detected at different ... Figure 2 SBP and HR of angiotensin II-infused mice were measured using a tail-cuff. (A) SBP was detected at different time points in each group (two-way ANOVA). (B) The HR was detected in the four groups. IL-12p35 KO = p35 KO. N = 8 in each group (two-way ANOVA). *P < 0.05 vs. the control group. <sup>#</sup>P < 0.05 vs. the Ang II-treated group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 5 Effect of IL-12p35 KO on SMC differentiation Figure 5 Effect of IL-12p35 KO on SMC differentiation. (A) Aortic OPN and SM22a protein expression was detected by ... Figure 5 Effect of IL-12p35 KO on SMC differentiation. (A) Aortic OPN and SM22a protein expression was detected by immunofluorescence staining (×200); n = 5 in each group. *P < 0.05 vs. the control group. <sup>#</sup>P < 0.05 vs. the Ang II-treated group. (B) iNOS mRNA levels in macrophages and OPN and SM22a mRNA levels in SMCs were measured by RT-qPCR (two-way ANOVA). N = 5 in each group. IL-12p35 KO = p35 KO. *P < 0.05 vs. the WT Mø+WT CD4+Ang II group. <sup>#</sup>P < 0.05 vs. the KO Mø+WT CD4+Ang II group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4 Effect of IL-12p35 KO on M1 macrophage differentiation Figure 4 Effect of IL-12p35 KO on M1 macrophage differentiation. (A) Double immunofluorescence staining of anti-F4/80 ... Figure 4 Effect of IL-12p35 KO on M1 macrophage differentiation. (A) Double immunofluorescence staining of anti-F4/80 and anti-CD80 in the four groups (×200). (B–G) The mRNA expression levels of iNOS, IL-1β, IL-6, IL-17, TNF-α, and IFN-γ in each group were measured by RT-qPCR (two-way ANOVA). (D) The p-STAT1, T-STAT1, p-P65, T-P65, and GAPDH levels were measured by western blotting (two-way ANOVA). (E) Double immunofluorescence staining of anti-F4/80 and anti-p-P65 in the Ang II group and the Ang II+IL-12p35 group (200×). IL-12p35 KO = p35 KO. N = 5–6 in each group. *P < 0.05 vs. the control group. <sup>#</sup>P < 0.05 vs. the Ang II-treated group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 6 Effect of rIL-12 on SBP and vascular dysfunction Figure 6 Effect of rIL-12 on SBP and vascular dysfunction. (A) The SBP in each group was detected using a tail-cuff at ... Figure 6 Effect of rIL-12 on SBP and vascular dysfunction. (A) The SBP in each group was detected using a tail-cuff at different time points (one-way ANOVA). N = 8 in each group. (B, D) The effect of rIL-12 on ACh-or SNP-induced relaxation was measured in endothelial-intact aortas isolated from the four groups (one-way ANOVA). N = 5 in each group. (C) The effect of IL-22 on PE-induced contraction was measured in endothelial-intact aortas isolated from each group (one-way ANOVA). N = 5 in each group. (E) IL-12p40 and EBI3 protein expression levels were measured by immunofluorescence staining (×200); n = 8 in each group. (F) IL-12Rβ1 and gp130 mRNA levels in these groups were measured by RT-qPCR (one-way ANOVA); n = 8 in each group. *P < 0.05 vs. the Ang II+PBS group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 Effect of IL-12p35 KO on Ang II-induced vascular dysfunction Figure 3 Effect of IL-12p35 KO on Ang II-induced vascular dysfunction. (A) The effect of IL-12p35 KO on ACh-induced ... Figure 3 Effect of IL-12p35 KO on Ang II-induced vascular dysfunction. (A) The effect of IL-12p35 KO on ACh-induced relaxation was measured in endothelial-intact aortas isolated from the four groups (two-way ANOVA). (B) The effect of IL-12p35 KO on PE-induced contraction was measured in endothelial-intact aortas isolated from each group (two-way ANOVA). (C) The effect of IL-12p35 KO on SNP-induced relaxation was measured in endothelial-intact aortas isolated from each group (two-way ANOVA). (D) Effect of indomethacin on ACh-induced relaxation (two-way ANOVA). IL-12p35 KO=p35 KO. N = 6 in each group. *P < 0.05 vs. the control group. <sup>#</sup>P < 0.05 vs. the Ang II-treated group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 7 Plasma IL-12 levels in hypertensive patients Figure 7 Plasma IL-12 levels in hypertensive patients. (A) Plasma IL-12 levels in control subjects and hypertensive ... Figure 7 Plasma IL-12 levels in hypertensive patients. (A) Plasma IL-12 levels in control subjects and hypertensive patients were detected by ELISA (Mann–Whitney U test). (B, C) Correlation analysis of SBP, DBP, and IL-12 levels in hypertensive patients (Spearman's correlation analysis). ****P < 0.0001 vs. the control group. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Cardiovasc Res, Volume 115, Issue 6, 30 November 2018, Pages 1102–1113, https://doi.org/10.1093/cvr/cvy263 The content of this slide may be subject to copyright: please see the slide notes for details.