Evidence for platelet activation during human drug-induced anaphylaxis

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Presentation transcript:

Evidence for platelet activation during human drug-induced anaphylaxis. Evidence for platelet activation during human drug-induced anaphylaxis. (A) Platelet counts in blood of individuals from the NASA study presenting no (n = 67), mild (n = 37), or severe (n = 30) anesthesia-induced anaphylaxis and the same severe patients during follow-up visit (n = 30). (B) Platelet and (C) leukocyte counts of four cardiac surgery cases (black symbols) and their matched control (open symbols) pairs (identical symbols within a pair) from the NASA cohort indicated as percentage of baseline (left) and absolute counts (right). A smoothed trend line has been added to indicate average behavior of each group (second-order polynomic, three neighbors: red, patients; green, controls). *P < 0.05, unpaired t test of cases versus controls, considering all values in the 3- to 4-hour interval (gray area). (D) CD62P-expressing platelets (left, percentage; right, geometric mean CD62P minus isotype staining) from the NASA study patients presenting no (n = 73), mild (n = 35), or severe (n = 29) anesthesia-induced anaphylaxis or the same mild (n = 35) or severe (n = 29) patients during follow-up visit. (A and D) Statistically significant differences between groups of anesthetized subjects ($P < 0.05, $$$P < 0.001, and $$$$P < 0.0001) and within a group of subjects comparing two different time points (##P < 0.01, ###P < 0.001, and ####P < 0.0001. Héloïse Beutier et al. Sci. Immunol. 2018;3:eaan5997 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works