Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using norplant™: a pilot study Anna F Glasier, M.D.,

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Presentation transcript:

Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using norplant™: a pilot study Anna F Glasier, M.D., Hong Wang, Ph.D., Jane E Davie, M.B.Ch.B., R.W Kelly, Ph.D., Hilary O.D Critchley, M.D.a Fertility and Sterility Volume 77, Issue 2, Pages 366-372 (February 2002) DOI: 10.1016/S0015-0282(01)02997-1

FIGURE 1 Study design. Glasier. RU486 and Norplant™treated endometrium. Fertil Steril 2002. Fertility and Sterility 2002 77, 366-372DOI: (10.1016/S0015-0282(01)02997-1)

FIGURE 2 Semiquantitative immunostaining scores (median value) of progesterone receptor (PgR) (A and B isoforms), progesterone receptor B (PgRB) isoform, and estrogen receptor (ER) in endometrium after placebo and after mifepristone. 0 = no immunostaining; 3 = intense immunostaining. Glasier. RU486 and Norplant™treated endometrium. Fertil Steril 2002. Fertility and Sterility 2002 77, 366-372DOI: (10.1016/S0015-0282(01)02997-1)

FIGURE 3 Strong positive nuclear progesterone receptor (PgR) immunostaining (brown) was observed in glands and stroma of endometrium treated with (a) Norplant™ and (b) mifepristone-Norplant™. (c), Lower positive progesterone receptor B (PgRB) immunostaining was apparent in glands and stroma of Norplant™treated endometrium. (d), Positive progesterone receptor B (PgRB) immunostaining was present in few cells of glands and stroma of mifepristone-Norplant™treated endometrium. (e), Strong estrogen receptor (ER) immunostaining was observed in glands and stroma of Norplant™treated endometrium. (f), Intense estrogen receptor (ER) immunostaining was observed in glands and stroma of endometrium treated with mifepristone-Norplant™. Glasier. RU486 and Norplant™treated endometrium. Fertil Steril 2002. Fertility and Sterility 2002 77, 366-372DOI: (10.1016/S0015-0282(01)02997-1)