Interactive effect of family history and environmental factors on respiratory tract–related morbidity in infancy Sandra Kuiper, PhD, Jean W.M. Muris,

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Presentation transcript:

Interactive effect of family history and environmental factors on respiratory tract–related morbidity in infancy Sandra Kuiper, PhD, Jean W.M. Muris, MD, PhD, Edward Dompeling, MD, PhD, Arnold D.M. Kester, PhD, Geertjan Wesseling, MD, PhD, J. André Knottnerus, MD, PhD, Constant P. van Schayck, PhD Journal of Allergy and Clinical Immunology Volume 120, Issue 2, Pages 388-395 (August 2007) DOI: 10.1016/j.jaci.2007.03.038 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Wheezing ever. Effect of family history on wheezing ever in infants (not) exposed to Der p 1 and PPS. 95% CI (Der p 1 < 2000/PPS no), 1.1-3.4; 95% CI (Der p 1 < 2000/PPS yes), 2.5-13.8; 95% CI (Der p 1 ≥ 2000/PPS no), 2.8-36.3; 95% CI (Der p 1 ≥ 2000/PPS yes), 6.9-137.2. Adjusted for other reported risk factors. Journal of Allergy and Clinical Immunology 2007 120, 388-395DOI: (10.1016/j.jaci.2007.03.038) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Attacks of wheezing. Effect of family history on attacks of wheezing in infants (not) exposed to Der p 1 and PPS. 95% CI (Der p 1 < 2000/PPS no), 1.2–4.1; 95% CI, (Der p 1 < 2000/PPS yes), 2.7-16.9; 95% CI (Der p 1 ≥ 2000/PPS no), 2.4-21.0; 95% CI Der p 1 ≥ 2000/PPS yes), 5.9-115.6. Adjusted for other reported risk factors. Journal of Allergy and Clinical Immunology 2007 120, 388-395DOI: (10.1016/j.jaci.2007.03.038) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Effect of family history on parentally reported tonsillitis and otitis media, as well as GP-registered acute otitis media, in infants who were breast-fed or received formula feeding. No BF, Exclusively formula feeding; BF, breast-feeding. Tonsillitis: 95% CI (No BF), 2.1–39.7; 95% CI (BF yes), 0.8–3.8. Parentally reported otitis media: 95% CI (No BF), 1.3–9.4; 95% CI, (BF yes), 0.6–2.0. GP-registered acute otitis media: 95% CI (No BF), 1.1–7.2; 95% CI (BF yes), 0.4-1.3. Adjusted for other reported risk factors. Journal of Allergy and Clinical Immunology 2007 120, 388-395DOI: (10.1016/j.jaci.2007.03.038) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions