Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways after pressure overload. Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways.

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Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways after pressure overload. Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways after pressure overload. The phosphorylation level of TβR1, TAK1 and JNK were measured by western blot in the myocardium of non-transgenic (NTG), tomoregulin-1-knockdown and tomoregulin-1-overexpression mice at 4 weeks after sham and TAC operation (A). The quantitative analysis of the level of phosphorylated TβR1 (B) use TβR1 for normalization, phosphorylated TAK1 (C) and JNK (D), and total TAK1 (E) and JNK (F), use GAPDH for normalization (n=3 independent experiments, *P<0.05, **P<0.01, ***P<0.001 versus NTG mice). Dan Bao et al. Dis. Model. Mech. 2015;8:795-804 © 2015. Published by The Company of Biologists Ltd