New diabetes stratification

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Presentation transcript:

New diabetes stratification A data-driven cluster analysis of six variables: age at diagnosis, BMI, HbA1c, β-cell function, insulin resistance, and GADA Type of diabetes Main characteristics SAID Early onset, low BMI, poor metabolic control, insulin deficiency, GADA positive SIDD Early onset, low BMI, poor metabolic control, low insulin secretion, GADA negative SIRD Insulin resistance, high BMI MOD No insulin resistance, high BMI MARD Older patients with modest metabolic derangements SAID: severe autoimmune diabetes; SIDD: severe insulin-deficient diabetes; SIRD: severe insulin resistant diabetes; MOD: mild obesity-related diabetes; MARD: mild age-related diabetes; GADA: glutamate decarboxylase antibodies; BMI: body-mass-index; Ahlqvist E, et al. Lancet Diab Endocrinol 2018