Preformation and induction models of PGC specification.

Slides:

Advertisements

Similar presentations

Ventral anterior (rostral) posterior (caudal) dorsal OUR AXIS.

Advertisements

Chapter 11 Germ cells, fertilization and sex The development of germ cells Gametes: eggs and sperm Determination of the sexual phenotype Sex chromosomes.

Drosophila dorsal/ventral axis detemination

Somatic, Germ and Stem cells 1)Distinctions between somatic and germ cells. 2)Establishment of somatic cell types. 3)Establishment of the germ line. 4)Fundamental.

Figure 2.26 Some examples of alternative RNA splicing.

Zebrafish Jeopardy General Characteristics Cell Movements Signaling and Pathways Developmental Stages Experiments

The Germ Line: Additional Concepts

Somatic, Germ and Stem cells

Early Development of Vertebrates

Human Embryology. segmentation and patterning somites.

Exploring Derivation of Germ Cells from Pluripotent Stem Cells

STEM CELLS: A Review.

Somatic, Germ and Stem cells

Primordial germ cell specification

The fate of neural crest cells

Xiu-Zhen Zhang Reproductive BioMedicine Online

SGN24 The Genetic Basis of Development

Pluripotency Takes Off without Blimp1

Paola Romagnani, Benjamin D. Humphreys Kidney International

The node of the mouse embryo

Emerging Asymmetry and Embryonic Patterning in Early Mouse Development

Male Germ Cell Specification and Differentiation

Volume 10, Issue 2, Pages (February 2018)

Chemical-Induced Naive Pluripotency

Gametogenesis from Pluripotent Stem Cells

Axis Development and Early Asymmetry in Mammals

Vertex Models of Epithelial Morphogenesis

Nodal Signaling in Early Vertebrate Embryos

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development Charles E. Murry, Gordon Keller Cell

Silencing of transposon RNAs during oogenesis is essential for embryonic development. Silencing of transposon RNAs during oogenesis is essential for embryonic.

Volume 10, Issue 2, Pages (February 2018)

Volume 11, Issue 1, Pages (July 2012)

Drosophila oogenesis Current Biology

Help Gina and Tina colour the numbers

Natalie Denef, Trudi Schüpbach Current Biology

TGFβ and SMADs Talk to NANOG in Human Embryonic Stem Cells

Transcriptome Encyclopedia of Early Human Development

The pluripotency cycle.

Fig. 2. Mapping of the interaction domain on coilin for association with the dyskerin complex. Mapping of the interaction domain on coilin for association.

Fig. 4. The model of malate metabolism in fruit cells under different K level conditions. The model of malate metabolism in fruit cells under different.

Fig. 2. Morphological analysis of acentriolar mitotic spindles

Directed differentiation of hPSCs.

The transcriptional network for primordial germ cell specification.

The derivation of hESCs and hiPSCs.

HEAT repeats as part of large protein complexes.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Schematic of the events during early otic development in zebrafish

Fig. 3. Immunostaining for neural differentiation makers of the stage 29 optic cup.Immunoreactive signals are shown in green or red. Immunostaining for.

Axial organisation of gastruloids.

Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours. Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours.

Overview of HEAT-motif-containing proteins.

Functions of p53 in the differentiation of human and mouse ESCs

Identification of a functional domain in MKL1_S that allows specific transcriptional activity. Identification of a functional domain in MKL1_S that allows.

Embryonic Cleavage Cycles: How Is a Mouse Like a Fly?

Signaling by apoptotic cells.

Fig. 2. Tbx1 lineage is largely complementary to the NSD

Self-organization into organoids, gastruloids and embryoids.

Model of Eomes action in gastrulation.

Yohei Hayashi, Ph. D. , Mitinori Saitou, M. D. , Ph. D

Fig. 2. Coupling of actin to cell–cell junctions requires α-catenin and is necessary for the establishment of the barrier.(A) Effect of Cytochalasin D.

Fig. 1. Generation of induced pluripotent stem cells (iPSCs) from urine cells (UC). Generation of induced pluripotent stem cells (iPSCs) from urine cells.

Misfolding mutations impair the BRCA1 nuclear aggregation in yeast and the BRCA1 nuclear localization in human cells. Misfolding mutations impair the BRCA1.

Kinetics of BDNF-induced Erk, Akt and PLCγ activation in the presence of 15 mM NaCl or 15 mM KCl. Representative western blots (A) and quantitative plots.

Fig. 8. Expression of other genomic-clustered Chrn subunits in the mesodiencephalon.(A) Schematic representation illustrating the assembly of the Chrnb4,

Proliferative and morphological defects following TbCALM and TbEpsinR depletion. Proliferative and morphological defects following TbCALM and TbEpsinR.

The impact of FIH-1 on ASPP2 protein interactions.

Effect of siRNA-mediated depletion of selected OST subunits on stability. Effect of siRNA-mediated depletion of selected OST subunits on stability. (A)

Schematics of mechanisms behind compartmentalization of RBPs on microtubules. Schematics of mechanisms behind compartmentalization of RBPs on microtubules.

Presentation transcript:

Preformation and induction models of PGC specification. Preformation and induction models of PGC specification. Schematic representation of the two modes of germ cell specification. (A) Preformation, as occurs in Drosophila. The nurse cells synthesise RNAs and proteins (pink) that are localised to the posterior pole of the oocyte. This germ plasm will be segregated into PGCs. (B) Induction, as occurs in the mouse. Signals from the extra-embryonic ectoderm (grey) induce the formation of PGCs (dark pink) from within pluripotent epiblast (red). Non-induced cells (green) go on to form the soma. ExE, extra-embryonic ectoderm; VE, visceral endoderm (brown). Adapted from Extavour and Akam (Extavour and Akam, 2003). Harry G. Leitch, and Austin Smith Development 2013;140:2495-2501 © 2013. Published by The Company of Biologists Ltd