Asj-2J mice show a progressive age-dependent increase in calcification in aorta, muzzle skin containing the dermal sheath of the vibrissae, kidney, spleen.

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Asj-2J mice show a progressive age-dependent increase in calcification in aorta, muzzle skin containing the dermal sheath of the vibrissae, kidney, spleen and lung. Asj-2J mice show a progressive age-dependent increase in calcification in aorta, muzzle skin containing the dermal sheath of the vibrissae, kidney, spleen and lung. (A) Tissue calcification levels were measured in 2- to 14-week-old WT, Asj-2J het (HET) and Asj-2J hom (HOM) mice from various tissues using a quantitative calcium assay. Each age group is represented by separate cohorts of mice (n=10 mice/group). (B) Body weight was monitored in WT and Asj-2J hom male and female mice beginning at 3 weeks of age (n=5 mice/group). (C) Representative µCT images of the WT and Asj-2J hom mice used in A. Scans focused on the cranial region of mice and show the dermal sheath of vibrissae, ear and ocular areas of mineralization development. All data are mean±s.e.m. *P<0.05, **P<0.005 and ***P<0.0005, compared with 2-week-old Asj-2J hom group (by Kruskal–Wallis test, followed by Dunn's multiple comparison test). Tayeba Khan et al. Dis. Model. Mech. 2018;11:dmm035691 © 2018. Published by The Company of Biologists Ltd