A new regulator of the vacuolar H+-ATPase in the kidney

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A new regulator of the vacuolar H+-ATPase in the kidney Dominique Eladari, Jacques Teulon Kidney International Volume 80, Issue 9, Pages 907-909 (November 2011) DOI: 10.1038/ki.2011.220 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Complex arrangement of ion transport systems in intercalated cells. The newly identified Slc26a11 protein is expressed on the same membrane as the H+-ATPase, that is, in the apical membrane of A-type intercalated cells and in the basolateral membrane of B-intercalated cells. It may function as a Cl− channel or Cl−/HCO3− exchanger. Note the presence in these cells of other Cl−/HCO3− exchangers and, on the basolateral membrane, of the ClC-Kb chloride channel. Kidney International 2011 80, 907-909DOI: (10.1038/ki.2011.220) Copyright © 2011 International Society of Nephrology Terms and Conditions