Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than.

Slides:

Advertisements

Similar presentations

Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro: implications for treatment of ovarian hyperstimulation.

Advertisements

Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D.,

Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls Xiao-Ke Wu, M.D., Ph.D., Kirsimarja.

Clinically significant and sustained weight loss is achievable in obese women with polycystic ovary syndrome followed in a regular medical practice Lysanne.

Andrew J. Krentz, M.D., Elizabeth Barrett-Connor, M.D.

Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization–embryo.

A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio Anna Maria Fulghesu, M.D., Mario Ciampelli,

The antiandrogenic effect of flutamide improves uterine perfusion in women with polycystic ovary syndrome Silvia Ajossa, M.D., Stefano Guerriero, M.D.,

Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis Anuja Dokras, M.D., Ph.D., Shari.

Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome

MRNA expression pattern of insulin-like growth factor components of granulosa cells and cumulus cells in women with and without polycystic ovary syndrome.

Withdrawal of GnRH agonist decreases oestradiol and VEGF concentrations in high responders Li-Jun Ding, Bin Wang, Xiao-Yue Shen, Gui-Jun Yan, Ning-Yuan.

Kalliopi Kotsa, M. D. , Ph. D. , Maria P. Yavropoulou, M. D

Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis

Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic.

Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls Xiao-Ke Wu, M.D., Ph.D., Kirsimarja.

Insulin resistance in oligomenorrheic infertile women with non-polycystic ovary syndrome Shirei Ohgi, M.D., Koji Nakagawa, M.D., Ph.D., Rieko Kojima,

Day 4 Estradiol Levels Predict Pregnancy Success in Women Undergoing Controlled Ovarian Hyperstimulation for IVF John Y Phelps, M.D., Adam S Levine,

Study of circulating hepcidin in association with iron excess, metabolic syndrome, and BMP-6 expression in granulosa cells in women with polycystic ovary.

Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model Ramiro Quintana, M.D.,

Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary.

Rebecca A. Feldman, M. D. , Kathleen O'Neill, M. D. , Samantha F

The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1β, interleukin-6, and vascular endothelial.

Assisted reproductive technology in the United States: 1999 results generated from the American Society for reproductive medicine/society for assisted.

Growth hormone, insulin-like growth factor I, and leptin interaction in human cultured lutein granulosa cells steroidogenesis Maria Karamouti, M.D, Panagoula.

Whole sheep ovary cryopreservation and transplantation

Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro: implications for treatment of ovarian hyperstimulation.

Rahi Victory, M. D. , F. R. C. S. C. , Ghassan M. Saed, Ph. D

Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular.

Polycystic ovary morphology: age-based ultrasound criteria

Elevation of antimüllerian hormone in women with polycystic ovary syndrome undergoing assisted reproduction: effect of insulin Xing Yan Liu, M.Sc., Yun.

Doxycycline inhibits vascular leakage and prevents ovarian hyperstimulation syndrome in a murine model Ofer Fainaru, M.D., Ph.D., Mark D. Hornstein,

Mohamed Fawzy, M. D. , Mohamed Y. AbdelRahman, M. D. , Mohamed H

Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women.

Philip Kressin, M. D. , Eva-Maria Wolber, Ph. D. , Harald Wodrich, Ph

Follicle-stimulating hormone or human menopausal gonadotropin for ovarian stimulation in in vitro fertilization cycles: a meta-analysis Rina Agrawal,

Fertility and Sterility

Correlations between concentrations of interleukin-12 and interleukin-13 and lymphocyte subsets in the follicular fluid of women with and without polycystic.

Endocrine gland–derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome.

Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome Carlos Moran, M.D.,

Evidence for competing effects of body mass, hyperinsulinemia, insulin resistance, and androgens on leptin levels among lean, overweight, and obese women.

Pyridostigmine cotreatment for controlled ovarian hyperstimulation in low responders undergoing in vitro fertilization–embryo transfer Chung-Hoon Kim,

Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome Eung-Ji Lee, M.Sc., Bermseok Oh, Ph.D., Jong-Young.

Simvastatin improves biochemical parameters in women with polycystic ovary syndrome: results of a prospective, randomized trial Antoni J. Duleba, M.D.,

Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells Toshiaki Taketani, M.D., Yoshiaki.

Impact of laparoscopic ovarian drilling on anti-Müllerian hormone levels and ovarian stromal blood flow using three-dimensional power Doppler in women.

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.

Effects of hyperglycemia on the differential expression of insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion.

Lisa F. Schneider, M. D. , Sara E. Monaco, M. D. , Michelle P

Follicular blood flow is a better predictor of the outcome of in vitro fertilization–embryo transfer than follicular fluid vascular endothelial growth.

Effect of angiotensin-converting enzyme inhibitor on renal function in ovarian hyperstimulation syndrome in the rabbit Maria Jose G Teruel, Ph.D., Luis.

Paolo Moghetti, M.D. Fertility and Sterility

Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D.,

Upregulation of mRNA expression of vascular endothelial growth factor and its receptors by exogenous human chorionic gonadotropin in cultured oviduct.

Follicular phase serum levels of luteinizing hormone do not influence delivery rates in in vitro fertilization cycles down-regulated with a gonadotropin-releasing.

Sodium nitroprusside treatment during the superovulation process improves ovarian response and ovarian expression of vascular endothelial growth factor.

The luteinizing hormone β-subunit exon 3 (Gly102Ser) gene mutation is rare in Korean women with endometriosis and polycystic ovary syndrome Nam Keun.

Touraj Mahmoudi, M. Sc. , Hamid Gourabi, Ph. D. , Mahnaz Ashrafi, M. D

Direct injection of vascular endothelial growth factor into the ovary of mice promotes follicular development Ramiro Quintana, M.D., Laura Kopcow, M.D.,

Effect of long-term naltrexone treatment on endocrine profile, clinical features, and insulin sensitivity in obese women with polycystic ovary syndrome

Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation Reshef.

Adiponectin levels reflect the different phenotypes of polycystic ovary syndrome: study in normal weight, normoinsulinemic patients Artemis Karkanaki,

Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian.

Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles

Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis

Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing.

The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production Antonio Pellicer, M.D., Carmela Albert,

In vitro viability and secretory capacity of human luteinized granulosa cells after gonadotropin-releasing hormone agonist trigger of oocyte maturation

Stephen J Winters, M. D. , Evelyn Talbott, David S Guzick, Ph. D. , M

Enrico Carmina, M.D., Rogerio A Lobo, M.D. Fertility and Sterility

Presentation transcript:

Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than in women with normal ovaries Rina Agrawal, M.D., Ph.D., Howard Jacobs, F.R.C.O.G.F.R.C.P., Nadia Payne, M.S.C., Gerard Conway, F.R.C.P. Fertility and Sterility Volume 78, Issue 6, Pages 1164-1169 (December 2002) DOI: 10.1016/S0015-0282(02)04242-5

FIGURE 1 Time and dose–response curve for vascular endothelial growth factor (VEGF) concentrations 1, 2, 4, 6, 9, and 12 days after culture with hormone concentrations of 0.1 IU (squares), 0.5 IU (diamonds), 1.0 IU (circles), and 5.0 IU (triangles) of hCG. Agrawal. VEGF released by human granulosa lutein cells. Fertil Steril 2002. Fertility and Sterility 2002 78, 1164-1169DOI: (10.1016/S0015-0282(02)04242-5)

FIGURE 2 Release of vascular endothelial growth factor (VEGF) by granulosa lutein cells obtained from women with polycystic ovaries or the polycystic ovary syndrome (shaded bars) and women with normal ovaries (black bars). Agrawal. VEGF released by human granulosa lutein cells. Fertil Steril 2002. Fertility and Sterility 2002 78, 1164-1169DOI: (10.1016/S0015-0282(02)04242-5)

FIGURE 3 Release of vascular endothelial growth factor (VEGF) by granulosa lutein cells obtained from women with polycystic ovaries (n = 10) who developed the ovarian hyperstimulation syndrome (n = 4) (shaded bars) and those who did not develop the ovarian hyperstimulation syndrome (n=6) (black bars) after 4 days of incubation with hCG and hCG plus insulin at a concentration of 1.0 IU. Agrawal. VEGF released by human granulosa lutein cells. Fertil Steril 2002. Fertility and Sterility 2002 78, 1164-1169DOI: (10.1016/S0015-0282(02)04242-5)