Identification of paracrine factors produced by satellite cells after exposure to matrix and necrotic cell debris for 24 hours. Identification of paracrine.

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Identification of paracrine factors produced by satellite cells after exposure to matrix and necrotic cell debris for 24 hours. Identification of paracrine factors produced by satellite cells after exposure to matrix and necrotic cell debris for 24 hours. (A–E) Matrix-NMD stimuli did not induce changes in the production of IGF-I (A), IGF-II (B), IGFBP-2 (C), IGFBP-5 (D) or IGFBP-6 (E). (F–L) Changes in production of some inflammatory cytokines were observed with matrix and NMD exposure: IL-1α (F), IL-1β (G), IL-4 (H), IL-6 (I), IL-10 (J), TNFα (K) and MCP-1 (L). (M–O) Matrix and NMD co-stimuli enhanced the production of regenerative cytokines FGF-2 (M), HGF (N) and SDF-1 (O). **P≤0.02 versus treatments without NMD stimulus; ***P≤0.05 versus all other treatments; ****P≤0.06 versus all other treatments. Drew Kuraitis et al. Dis. Model. Mech. 2013;6:793-801 © 2013. Published by The Company of Biologists Ltd