Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

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Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in immunocompetent mice. Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in immunocompetent mice. (A–C) HE-stained photomicrographs of skin sections from BALB/C mice: (A) no treatment, (B) challenged with ethanol and (C) challenged with oxazolone. (D–F) HE-stained skin sections from NOD-scid IL2Rγnull mice: (D) non-engrafted no treatment, (E) non-engrafted challenged with oxazolone and (F) engrafted challenged with oxazolone. Arrows indicate epithelial hyperplasia. Scale bars: 50 μm. Thomas Nolte et al. Dis. Model. Mech. 2013;6:125-134 © 2012. Published by The Company of Biologists Ltd