Hypoacidity, anemia and hypergastrinemia in KI/KI mice.

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Hypoacidity, anemia and hypergastrinemia in KI/KI mice. Hypoacidity, anemia and hypergastrinemia in KI/KI mice. (A) Gastric pH values determined by direct measurement with colorimetric paper at necropsy. Measurements of two different animals are shown for each genotype; gastric pH values were ∼1, ∼4 and ∼7 for WT, KI/+ and KI/KI mice, respectively. (B) Ferritin concentrations in plasma (mM) of WT, KI/+ and KI/KI male (left) and female (right) mice. (C) Gastrin concentrations in serum (pM) of WT, KI/+ and KI/KI mice at ages indicated. (D) Representative IHC images of the antrum region of the stomach stained with anti-gastrin antibody in WT and KI/KI mice at 350 days of age. In both genotypes, the anti-gastrin antibody labels G-cells at the base of pyloric glands (black arrows). (E) IHC with anti-Ki67 antibody of the gastric antrum from representative WT and KI/KI mice. In both genotypes, progenitor cells are located at the base of pyloric glands (asterisks). (F) Gastrin concentrations in serum (pM) of WT, KI/+ and KI/KI mice. n=6 per genotype. ns, not significant. Data in B,C,F are represented as mean±s.d. Oriol Calvete et al. Dis. Model. Mech. 2016;9:975-984 © 2016. Published by The Company of Biologists Ltd