Volume 63, Issue 5, Pages (May 2003)

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Volume 63, Issue 5, Pages 1785-1790 (May 2003) Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat Snigdha Priyadarshi, Brandon Valentine, Chi Han, Olga V. Fedorova, Alexei Y. Bagrov, Jiang Liu, Sankaridrug M. Periyasamy, David Kennedy, Deepak Malhotra, Zijian Xie, Joseph I. Shapiro Kidney International Volume 63, Issue 5, Pages 1785-1790 (May 2003) DOI: 10.1046/j.1523-1755.2003.00914.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Na-K-ATPase activity in hearts isolated from sham-operated rats (N = 8) as well as rats subjected to partial nephrectomy (PNx) given drinking water alone (N = 8) or supplemented with 0.1% (N = 8) and 0.25% (N = 8) green tea extract (GT). #P < 0.01 vs. sham-operated animals. Kidney International 2003 63, 1785-1790DOI: (10.1046/j.1523-1755.2003.00914.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Effect of partial nephrectomy (PNx) on the plasma concentrations of substances that crossreact with digitalis, marinobufagenin (MBG), and ouabain antibodies. We considered these substances, digitalis-like compound (DLC), MBG, and ouabain-like compound (OLC). *P < 0.05; #P < 0.01 vs. control. Kidney International 2003 63, 1785-1790DOI: (10.1046/j.1523-1755.2003.00914.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Representative fluorescence imaging spectroscopy experiment obtained from adult cardiac myocytes loaded with 5 and 6 chloromethyl 2H, 7H dichlorofluorescein (CMD-CFH). Representative images shown with pseudo color intensity from -5, 0, 5, 10, and 15 minutes relative to administration of marinobufagenin (MBG) (100 nmol/L). We have also displayed a plot of fluorescence intensity over time in each of the 24 voxels picked within the three myocytes imaged. Average fluorescence values were fit with linear regression before and following addition of the MBG (red lines on graph). Kidney International 2003 63, 1785-1790DOI: (10.1046/j.1523-1755.2003.00914.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Effect of green tea extract (GT) on CMD-CFH fluorescence in adult cardiac myocytes. Data shown as mean ± SEM of 15 determinations at 3, 9, 12, and 15 minutes following addition of either ouabain (10 μmol/L) or marinobufagenin (MBG) (100 nmol/L) alone or in combination with GT (50 μg/mL). Data normalized to pretreatment value of 1.0. Note that time control samples showed increase in fluorescence over time. Fluorescence in cells treated with GT alone increased at a rate comparable to control (data not shown). *P < 0.05; #P < 0.01 vs. control. Kidney International 2003 63, 1785-1790DOI: (10.1046/j.1523-1755.2003.00914.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Effect of green tea extract (GT) (50 μg/mL) on (3H)phenylalanine incorporation following exposure to ouabain (10 μmol/L) or marinobufagenin (MBG) (100 nmol/L). Data shown as mean ± SEM of 15 determinations. #P < 0.01 vs. control. Kidney International 2003 63, 1785-1790DOI: (10.1046/j.1523-1755.2003.00914.x) Copyright © 2003 International Society of Nephrology Terms and Conditions