Volume 70, Issue 6, Pages (September 2006)

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Volume 70, Issue 6, Pages 989-993 (September 2006) Modulator of bone morphogenetic protein activity in the progression of kidney diseases M. Yanagita Kidney International Volume 70, Issue 6, Pages 989-993 (September 2006) DOI: 10.1038/sj.ki.5001731 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Working hypothesis. (a) In kidney diseases, injured PTECs undertake apoptosis and EMT, and produce inflammatory cytokines. BMP-7 secreted from distal tubules is known to inhibit apoptosis, EMT, and production of cytokines of PTEC. USAG-1 is secreted from distal tubules, binds to BMP-7, and inhibits the binding of BMP-7 to its receptors. (b) Drugs or neutralizing antibodies that inhibits binding between USAG-1 and BMP, or gene-silencing therapy for USAG-1 would increase available endogenous BMP, and might be a promising way to develop novel therapeutic methods for severe renal diseases. (c) Phylogenetic tree of BMP antagonists. Phylogenetic tree of human BMP antagonists based on the overall amino-acid sequence similarity. GenomeNet server at http://www.genome.jp/ was used for phylogenetic tree construction. Kidney International 2006 70, 989-993DOI: (10.1038/sj.ki.5001731) Copyright © 2006 International Society of Nephrology Terms and Conditions