Genetic Polymorphisms in the Polycomb Group Gene EZH2 and the Risk of Lung Cancer Kyong-Ah Yoon, MD, Hye Jin Gil, MS, Jihye Han, MS, Jaehee Park, MS,

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Genetic Polymorphisms in the Polycomb Group Gene EZH2 and the Risk of Lung Cancer Kyong-Ah Yoon, MD, Hye Jin Gil, MS, Jihye Han, MS, Jaehee Park, MS, Jin Soo Lee, MD Journal of Thoracic Oncology Volume 5, Issue 1, Pages 10-16 (January 2010) DOI: 10.1097/JTO.0b013e3181c422d9 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Gene maps, haplotypes, and linkage disequilibriums (LDs) of EZH2 single nucleotide polymorphisms (SNPs). Coding exons are marked by black blocks and 5′ and 3′ UTRs by white blocks. The first base of the translational start site is denoted as nucleotide +1. Asterisks indicate the SNPs that were used for the statistical analysis. A, SNPs genotyped in the study subjects. The frequencies of the SNPs were based on findings in 670 subjects (335 patients with lung cancer and 335 normal controls). B, Five common haplotypes of EZH2 with a frequency of >0.06. C, LD block in EZH2 identified using Haploview. Journal of Thoracic Oncology 2010 5, 10-16DOI: (10.1097/JTO.0b013e3181c422d9) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions