Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy Olivier Michel,

Slides:

Advertisements

Similar presentations

Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia.

Advertisements

Assessment of inflammation in noninfectious chronic maxillary sinusitis Pascal Demoly, MDa, Louis Crampette, MDb, Michel Mondain, MDb, Alison M. Campbell,

W.Travis Cain, MDa, Greg Cable, PhDb, John J. Oppenheimer, MDc

Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis Teruo Shiomori, MDa, Shin-ichi Yoshida, MD, PhDb,

Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison.

Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial Peter Alexander Blanch Wark,

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

The editors’ choice Journal of Allergy and Clinical Immunology

Eosinophil cationic protein and histamine after intestinal challenge in patients with cow's milk intolerance Ulf Bengtsson, MD, PhDa, Tina W. Knutson,

Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma Patrick Booms, MSca, David.

Ulf Darsow, MD, Dieter Vieluf, MD, Johannes Ring, MD, PhD

Asthma and increased bronchial responsiveness in elite athletes: Atopy and sport event as risk factors Ilkka J. Helenius, MDa, Heikki O. Tikkanen, MDb,

Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma Malgorzata Pierzchalska,

Badrul A. Chowdhury, MD, PhD

Chronic sinusitis in severe asthma is related to sputum eosinophilia

Inflammation of small airways in asthma

Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma Annika Wallin, PhDa, Malcolm Sue-Chu, PhDb, Leif Bjermer,

Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma

Elephantiasis nostras: A case report

Paul Van Durme, MDa, Jan L. Ceuppens, MD, PhDa,b, Pascal Cadot, PhDb

Erythema multiforme to phenobarbital: Involvement of eosinophils and T cells expressing the skin homing receptor F.Jesus Gonzalez, PhDa, Maria J. Carvajal,

Evidence for expression of eosinophil-associated IL-12 messenger RNA and immunoreactivity in bronchial asthma Esra Nutku, MDa, Abdelilah Soussi Gounni,

News & Notes Journal of Allergy and Clinical Immunology

Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype Atsuko Takao, MDa, Terufumi Shimoda, MDa, Shigeru Kohno, MDa, Sadahiro.

Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity Sinforiano J. Posadas, PhDa, Antonia Padial,

Circadian variation of sputum inflammatory cells in mild asthma

Selective allergic reactions to clavulanic acid

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

The editors' choice Journal of Allergy and Clinical Immunology

Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and.

Molecular virology and immunology of HIV infection

Exercise-induced bronchoconstriction in children: Montelukast attenuates the immediate-phase and late-phase responses Raul E. Melo, MD, Dirceu Solé,

Pia Isomäki, MD, PhDa, Gregorio Aversa, PhDb, Chia-Chun J

Vascular endothelial growth factor in patients with acute asthma

News & Notes Journal of Allergy and Clinical Immunology

No correlation between wine intolerance and histamine content of wine

F. Estelle R. Simons, MD, FRCPCa, Xiaochen Gu, PhDb, Keith J

Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma Yasurou Kohno, MDa,

TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced.

Assessment of inflammation in noninfectious chronic maxillary sinusitis Pascal Demoly, MDa, Louis Crampette, MDb, Michel Mondain, MDb, Alison M. Campbell,

A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein.

Fractional analysis of sequential induced sputum samples during sputum induction: Evidence that different lung compartments are sampled at different time.

Intracellular IL-5 and T-lymphocyte subsets in atopic and nonatopic bronchial asthma Yutaro Shiota, MD, PhDa, Hitomi Arikita, MTa, Naokatsu Horita, MDb,

Gail G. Shapiro, MDa, Timothy G

Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation Anthony P. Sampson, PhDa, Emilio Pizzichini, MD, PhDb,

Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects Neil E. Alexis,

Chemokines in seasonal allergic rhinitis

Renata J. M. Engler, MDa, Julie Kenner, MD, PhDb, Donald Y. M

Seasonal intestinal inflammation in patients with birch pollen allergy

Prognosis and prediction of response to surgery in allergic patients with chronic sinusitis François Lavigne, MDa, Cong Thu Nguyen, MDa, Lisa Cameron,

Allergy and asthma in elite summer sport athletes

IgE+ cells in the peripheral blood of atopic, nonatopic, and bee venom–hypersensitive individuals exhibit the phenotype of highly differentiated B cells

Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways Gert-Jan Braunstahl, MDa, b, Shelley.

13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo Paul A.J. Henricks, PhDa, Ferdi Engels,

Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway.

Determinants of systemic manifestations of food allergy

Rame A. Taha, MDa, Eleanor M. Minshall, PhDa, Donald Y. M

Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma Sun Ying,

Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma Sally E. Wenzel, MD Journal of Allergy and Clinical.

Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation Tricia D. LeVan, PhD, Olivier Michel,

Reply Journal of Allergy and Clinical Immunology

Prescott G. Woodruff, MD, MPH, Ramin Khashayar, MD, Stephen C

IL-18 might reflect disease activity in mild and moderate asthma exacerbation Hiroshi Tanaka, MD, Naomitsu Miyazaki, MD, Kensuke Oashi, MD, Shin Teramoto,

Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis Teruo Shiomori, MDa, Shin-ichi Yoshida, MD, PhDb,

Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression

News & Notes Journal of Allergy and Clinical Immunology

IL-1 receptor–type expression in relation to atopy

Diisocyanate antigen–enhanced production of monocyte chemoattractant protein-1, IL- 8, and tumor necrosis factor-α by peripheral mononuclear cells of workers.

Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner Tetsuya Adachi, MDa, Susan Stafford,

Pascal Chanez, MDa, Antonio M

Presentation transcript:

Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy Olivier Michel, MD, PhDa, Mieke Dentener, PhDb, Francis Corazza, MDa, Wim Buurman, MD, PhDc, Ragnar Rylander, MD, PhDd Journal of Allergy and Clinical Immunology Volume 107, Issue 5, Pages 797-804 (May 2001) DOI: 10.1067/mai.2001.114249 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 The time-related response induced by inhalation of 50 μg LPS (•) compared with saline solution (○). Results are means (±SE) of the changes in temperature (F test = 4.9, P < .01), FEV1 (F test = 3.1, P < .05), blood PMN count (F test = 55.3, P < .001), blood concentration in E-selectin (F test = 9.9, P < .001), CRP (F test = 11.9, P < .001), and LBP (F test = 24.5, P < .001). Wilcoxon paired test: *P < .05, **P < .02, ***P < .01. Journal of Allergy and Clinical Immunology 2001 107, 797-804DOI: (10.1067/mai.2001.114249) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 The association between the clinical responses to inhaled LPS with inflammation. Left, Compared with nonresponders (•), subjects who had a significant increase in body temperature (○; F test = 16.3, P < .01) also had larger responses in blood inflammatory markers: PMN (bPMN; F test = 7.6, P < .01), CRP (bCRP; F test = 6.9, P < .02), and LBP (bLBP; F test = 11.0, P < .01). Center, Compared with nonresponders (•), subjects with a significant increase in AR (○; F test = 4.5 P < .05) also had a significant rise in sputum ECP (sECP; F test = 8.4, P < .01), but not in sputum TNF (sTNF) or sputum MPO (sMPO). Right, Compared with nonresponders (•), subjects with a significant decrease in FEV1 (○; F test = 31.2, P < .001) were not significantly associated with the response in sputum ECP (F test = 1.1, P > .1 ), TNF (F test = 2.9, P = .09), or MPO (F test = 3.0, P = .09). Mann-Whitney tests: *P < .05, **P < .02, ***P < .01. PMNs are expressed in cells per microliter, CRP in milligrams per liter, LBP in milligrams per liter, FEV1 as a percentage, ECP in nanograms per milliliter, TNF in picograms per milliliter, and MPO in nanograms per milliliter. All data are means ± SE. Journal of Allergy and Clinical Immunology 2001 107, 797-804DOI: (10.1067/mai.2001.114249) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 The association between the clinical and inflammatory responses to inhaled LPS with atopy (ie, SPT ≥ 4 mm). Left, Compared with atopic subjects (○), the amplitude of the systemic response is larger in nonatopic subjects (•): increase in body temperature (°C; F test = 14.8, P < .001), blood PMN (bPMNs; F test = 6.9, P < .01), and blood LBP (bLBP; F test = 5.2, P < .03), but not blood CRP (bCRP). Right, Nonatopic subjects (•) had a larger decrease in FEV1 (F test = 8.9, P < .01; upper panel ) but not in AR, sputum ECP (sECP), or sputum MPO (sMPO) (lower 3 panels). Mann-Whitney tests: *P < .05, **P < .02. PMNs are expressed in cells per microliter, CRP in milligrams per liter, LBP in milligrams per liter, FEV1 as a percentage, ECP in nanograms per milliliter, TNF in picograms per milliliter, and MPO in nanograms per milliliter. All data are means ± SE. Journal of Allergy and Clinical Immunology 2001 107, 797-804DOI: (10.1067/mai.2001.114249) Copyright © 2001 Mosby, Inc. Terms and Conditions