Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass Shun-Jia Hong, Ph.D., Philip Chi-Ngong.

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Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass Shun-Jia Hong, Ph.D., Philip Chi-Ngong Chiu, Ph.D., Kai-Fai Lee, Ph.D., Jenny Yin-Mei Tse, Ph.D., Pak-Chung Ho, M.D., William Shu- Biu Yeung, Ph.D. Fertility and Sterility Volume 92, Issue 3, Pages 971-978 (September 2009) DOI: 10.1016/j.fertnstert.2008.07.1760 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The acrosomal status of spermatozoa after penetrating various cumulus columns (n = 10) determined by fluorescein isothiocyanate–labeled peanut agglutinin staining. Values are median with interquartile range. a,bP<.05 between values with different superscripts. Fertility and Sterility 2009 92, 971-978DOI: (10.1016/j.fertnstert.2008.07.1760) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Effects of hyaluronic acid on spontaneous acrosome reaction (n = 10). Values are median and interquartile range. P<.05 compared with the medium-alone control. Fertility and Sterility 2009 92, 971-978DOI: (10.1016/j.fertnstert.2008.07.1760) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions