Comparison of ternary TCR-lipid-CD1 complex structures.

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Comparison of ternary TCR-lipid-CD1 complex structures.

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Presentation transcript:

Comparison of ternary TCR-lipid-CD1 complex structures. Comparison of ternary TCR-lipid-CD1 complex structures. Crystal structures of self-lipid presentation by CD1b (PG90 TCR-CD1b-PG) (A, D, and G) and CD1a [BK6 TCR–CD1a–lysophosphatidylcholine (LPC)] (B, E, and H) (29) and foreign antigen presentation by CD1b (GEM42 TCR-CD1b-GMM) (C, F, and I) (16). Blue and purple spheres, representing the center of mass of TCR α and β, respectively (D to F), footprints (red, bottom panels), and extent of antigen interaction (cyan), with antigen atoms not involved in the interaction in black (G to I). Ternary complexes (A to C) are shown in ribbon diagrams and bound lipid antigens as spheres. Blue, scaffold lipids; dark green, PG; orange, LPC; yellow, GMM. Adam Shahine et al. Sci. Immunol. 2017;2:eaao1384 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).